Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Steussy, Bryan, Lekostaj, Jacqueline, Qian, Qining, Rosenthal, Nancy, Holman, Carol J., Syrbu, Sergei, Darbro, Benjamin, Bossler, Aaron, Karandikar, Nitin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Case Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243928/
https://www.ncbi.nlm.nih.gov/pubmed/27069033
http://dx.doi.org/10.1093/labmed/lmw011
Descripción
Sumario:We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)–like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

Ejemplares similares