Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cel...

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Autores principales: Steussy, Bryan, Lekostaj, Jacqueline, Qian, Qining, Rosenthal, Nancy, Holman, Carol J., Syrbu, Sergei, Darbro, Benjamin, Bossler, Aaron, Karandikar, Nitin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Case Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243928/
https://www.ncbi.nlm.nih.gov/pubmed/27069033
http://dx.doi.org/10.1093/labmed/lmw011
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author Steussy, Bryan
Lekostaj, Jacqueline
Qian, Qining
Rosenthal, Nancy
Holman, Carol J.
Syrbu, Sergei
Darbro, Benjamin
Bossler, Aaron
Karandikar, Nitin J.
author_facet Steussy, Bryan
Lekostaj, Jacqueline
Qian, Qining
Rosenthal, Nancy
Holman, Carol J.
Syrbu, Sergei
Darbro, Benjamin
Bossler, Aaron
Karandikar, Nitin J.
author_sort Steussy, Bryan
collection PubMed
description We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)–like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.
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spelling pubmed-72439282020-05-27 Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman Steussy, Bryan Lekostaj, Jacqueline Qian, Qining Rosenthal, Nancy Holman, Carol J. Syrbu, Sergei Darbro, Benjamin Bossler, Aaron Karandikar, Nitin J. Lab Med Case Studies We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)–like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm. Oxford University Press 2016-05 2016-04-11 /pmc/articles/PMC7243928/ /pubmed/27069033 http://dx.doi.org/10.1093/labmed/lmw011 Text en © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Studies
Steussy, Bryan
Lekostaj, Jacqueline
Qian, Qining
Rosenthal, Nancy
Holman, Carol J.
Syrbu, Sergei
Darbro, Benjamin
Bossler, Aaron
Karandikar, Nitin J.
Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title_full Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title_fullStr Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title_full_unstemmed Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title_short Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman
title_sort leukemic transdifferentiation of follicular lymphoma into an acute histiocytic leukemia in a 52-year-old caucasian woman
topic Case Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243928/
https://www.ncbi.nlm.nih.gov/pubmed/27069033
http://dx.doi.org/10.1093/labmed/lmw011
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