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Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway

Histone deacetylase inhibitors (HDACi) are an emerging cancer therapy; however, their effect on natural killer (NK) cell-mediated anti-tumor responses remain unknown. Here, we evaluated the impact of a benzamide HDACi, entinostat, on human primary NK cells as well as tumor cell lines. Entinostat sig...

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Detalles Bibliográficos
Autores principales:	Idso, John M., Lao, Shunhua, Schloemer, Nathan J., Knipstein, Jeffrey, Burns, Robert, Thakar, Monica S., Malarkannan, Subramaniam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244011/ https://www.ncbi.nlm.nih.gov/pubmed/32499867 http://dx.doi.org/10.18632/oncotarget.27546

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