TGF-β signaling regulates SPOP expression and promotes prostate cancer cell stemness

SPOP, a substrate binding adaptor of E3 ubiquitin ligase Cullin3, is frequently mutated in human prostate cancer (PCa). However, whether and how SPOP is regulated at transcriptional level in PCa remain unclear. Here, we report that SPOP is down-regulated in PCa stem-like cells (CSCs) and tissues. Ou...

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Detalles Bibliográficos
Autores principales: Jiao, Chenchen, Meng, Tong, Zhou, Chenyu, Wang, Xinbo, Wang, Ping, Lu, Meiling, Tan, Xiao, Wei, Qing, Ge, Xin, Jin, Jiali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244043/
https://www.ncbi.nlm.nih.gov/pubmed/32364525
http://dx.doi.org/10.18632/aging.103085

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