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The shared KEGG pathways between icariin-targeted genes and osteoporosis

Osteoporosis is a common metabolic bone disease that affects about 40% of postmenopausal women. Treatment options for osteoporosis are limited, however. Icariin is an herbal substance that has been shown to improve bone mass, but the mechanisms are largely unknown. Using bioinformatics analysis, we...

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Autores principales: Yu, Tao, Xiong, Yuan, Luu, Simon, You, Xiaomeng, Li, Bing, Xia, Jiang, Zhu, Hui, Zhao, Youguang, Zhou, Haichao, Yu, Guangrong, Yang, Yunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244047/
https://www.ncbi.nlm.nih.gov/pubmed/32380477
http://dx.doi.org/10.18632/aging.103133
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author Yu, Tao
Xiong, Yuan
Luu, Simon
You, Xiaomeng
Li, Bing
Xia, Jiang
Zhu, Hui
Zhao, Youguang
Zhou, Haichao
Yu, Guangrong
Yang, Yunfeng
author_facet Yu, Tao
Xiong, Yuan
Luu, Simon
You, Xiaomeng
Li, Bing
Xia, Jiang
Zhu, Hui
Zhao, Youguang
Zhou, Haichao
Yu, Guangrong
Yang, Yunfeng
author_sort Yu, Tao
collection PubMed
description Osteoporosis is a common metabolic bone disease that affects about 40% of postmenopausal women. Treatment options for osteoporosis are limited, however. Icariin is an herbal substance that has been shown to improve bone mass, but the mechanisms are largely unknown. Using bioinformatics analysis, we have identified the hub genes and KEGG pathways shared between icariin-targeted genes and osteoporosis. The top five shared KEGG pathways were the Toll-like receptor signaling pathway, adipocytokine pathway, neurotrophin signaling pathway, NOD-like receptor signaling, and B cell receptor signaling pathway; the hub genes were RELA, NFKBIA, and IKBKB, belonging to the NF-κB family. The identified icariin-targeted genes are involved in inflammation, insulin resistance, apoptosis, and immune responses, and regulate the PI3K-Akt, NF-κB, MAPK, and JNK signaling pathways. Our in vitro data show that icariin inhibits apoptosis in human mesenchymal stem cells by suppressing JNK/c-Jun signaling pathway. Together, these findings indicate that icariin exerts its anti-osteoporotic function by inhibiting JNK/c-Jun signaling pathway, and suggest that icariin may be a promising treatment option for osteoporosis.
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spelling pubmed-72440472020-06-03 The shared KEGG pathways between icariin-targeted genes and osteoporosis Yu, Tao Xiong, Yuan Luu, Simon You, Xiaomeng Li, Bing Xia, Jiang Zhu, Hui Zhao, Youguang Zhou, Haichao Yu, Guangrong Yang, Yunfeng Aging (Albany NY) Research Paper Osteoporosis is a common metabolic bone disease that affects about 40% of postmenopausal women. Treatment options for osteoporosis are limited, however. Icariin is an herbal substance that has been shown to improve bone mass, but the mechanisms are largely unknown. Using bioinformatics analysis, we have identified the hub genes and KEGG pathways shared between icariin-targeted genes and osteoporosis. The top five shared KEGG pathways were the Toll-like receptor signaling pathway, adipocytokine pathway, neurotrophin signaling pathway, NOD-like receptor signaling, and B cell receptor signaling pathway; the hub genes were RELA, NFKBIA, and IKBKB, belonging to the NF-κB family. The identified icariin-targeted genes are involved in inflammation, insulin resistance, apoptosis, and immune responses, and regulate the PI3K-Akt, NF-κB, MAPK, and JNK signaling pathways. Our in vitro data show that icariin inhibits apoptosis in human mesenchymal stem cells by suppressing JNK/c-Jun signaling pathway. Together, these findings indicate that icariin exerts its anti-osteoporotic function by inhibiting JNK/c-Jun signaling pathway, and suggest that icariin may be a promising treatment option for osteoporosis. Impact Journals 2020-05-07 /pmc/articles/PMC7244047/ /pubmed/32380477 http://dx.doi.org/10.18632/aging.103133 Text en Copyright © 2020 Yu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yu, Tao
Xiong, Yuan
Luu, Simon
You, Xiaomeng
Li, Bing
Xia, Jiang
Zhu, Hui
Zhao, Youguang
Zhou, Haichao
Yu, Guangrong
Yang, Yunfeng
The shared KEGG pathways between icariin-targeted genes and osteoporosis
title The shared KEGG pathways between icariin-targeted genes and osteoporosis
title_full The shared KEGG pathways between icariin-targeted genes and osteoporosis
title_fullStr The shared KEGG pathways between icariin-targeted genes and osteoporosis
title_full_unstemmed The shared KEGG pathways between icariin-targeted genes and osteoporosis
title_short The shared KEGG pathways between icariin-targeted genes and osteoporosis
title_sort shared kegg pathways between icariin-targeted genes and osteoporosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244047/
https://www.ncbi.nlm.nih.gov/pubmed/32380477
http://dx.doi.org/10.18632/aging.103133
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