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Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen

The ability to switch between glycolysis and ketosis promotes survival by enabling metabolism through fat oxidation during periods of fasting. Carbohydrate restriction or stress can also elicit metabolic switching. Keto-adapting from glycolysis is delayed in aged rats, but factors mediating this age...

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Autores principales: Hernandez, Abbi, Truckenbrod, Leah, Federico, Quinten, Campos, Keila, Moon, Brianna, Ferekides, Nedi, Hoppe, Meagan, D’Agostino, Dominic, Burke, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244089/
https://www.ncbi.nlm.nih.gov/pubmed/32369441
http://dx.doi.org/10.18632/aging.103116
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author Hernandez, Abbi
Truckenbrod, Leah
Federico, Quinten
Campos, Keila
Moon, Brianna
Ferekides, Nedi
Hoppe, Meagan
D’Agostino, Dominic
Burke, Sara
author_facet Hernandez, Abbi
Truckenbrod, Leah
Federico, Quinten
Campos, Keila
Moon, Brianna
Ferekides, Nedi
Hoppe, Meagan
D’Agostino, Dominic
Burke, Sara
author_sort Hernandez, Abbi
collection PubMed
description The ability to switch between glycolysis and ketosis promotes survival by enabling metabolism through fat oxidation during periods of fasting. Carbohydrate restriction or stress can also elicit metabolic switching. Keto-adapting from glycolysis is delayed in aged rats, but factors mediating this age-related impairment have not been identified. We measured metabolic switching between glycolysis and ketosis, as well as glycogen dynamics, in young and aged rats undergoing time-restricted feeding (TRF) with a standard diet or a low carbohydrate ketogenic diet (KD). TRF alone reversed markers of insulin-related metabolic deficits and accelerated metabolic switching in aged animals. A KD+TRF, however, provided additive benefits on these variables. Remarkably, the ability to keto-adapt was not related to glycogen levels and KD-fed rats showed an enhanced elevation in glucose following epinephrine administration. This study provides new insights into the mechanisms of keto-adaptation demonstrating the utility of dietary interventions to treat metabolic impairments across the lifespan.
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spelling pubmed-72440892020-06-03 Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen Hernandez, Abbi Truckenbrod, Leah Federico, Quinten Campos, Keila Moon, Brianna Ferekides, Nedi Hoppe, Meagan D’Agostino, Dominic Burke, Sara Aging (Albany NY) Research Paper The ability to switch between glycolysis and ketosis promotes survival by enabling metabolism through fat oxidation during periods of fasting. Carbohydrate restriction or stress can also elicit metabolic switching. Keto-adapting from glycolysis is delayed in aged rats, but factors mediating this age-related impairment have not been identified. We measured metabolic switching between glycolysis and ketosis, as well as glycogen dynamics, in young and aged rats undergoing time-restricted feeding (TRF) with a standard diet or a low carbohydrate ketogenic diet (KD). TRF alone reversed markers of insulin-related metabolic deficits and accelerated metabolic switching in aged animals. A KD+TRF, however, provided additive benefits on these variables. Remarkably, the ability to keto-adapt was not related to glycogen levels and KD-fed rats showed an enhanced elevation in glucose following epinephrine administration. This study provides new insights into the mechanisms of keto-adaptation demonstrating the utility of dietary interventions to treat metabolic impairments across the lifespan. Impact Journals 2020-05-05 /pmc/articles/PMC7244089/ /pubmed/32369441 http://dx.doi.org/10.18632/aging.103116 Text en Copyright © 2020 Hernandez et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Hernandez, Abbi
Truckenbrod, Leah
Federico, Quinten
Campos, Keila
Moon, Brianna
Ferekides, Nedi
Hoppe, Meagan
D’Agostino, Dominic
Burke, Sara
Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title_full Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title_fullStr Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title_full_unstemmed Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title_short Metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
title_sort metabolic switching is impaired by aging and facilitated by ketosis independent of glycogen
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244089/
https://www.ncbi.nlm.nih.gov/pubmed/32369441
http://dx.doi.org/10.18632/aging.103116
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