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Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential
There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244111/ https://www.ncbi.nlm.nih.gov/pubmed/32442231 http://dx.doi.org/10.1371/journal.pone.0233550 |
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author | Morimoto, Masahito Hashimoto, Toshiaki Tsuda, Yoshimi Nakatsu, Tadanori Kitaoka, Taisuke Kyotani, Shojiro |
author_facet | Morimoto, Masahito Hashimoto, Toshiaki Tsuda, Yoshimi Nakatsu, Tadanori Kitaoka, Taisuke Kyotani, Shojiro |
author_sort | Morimoto, Masahito |
collection | PubMed |
description | There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 ASD children, samples were plasma. The subjects were divided into age groups: toddlers/preschool age (2–6 years) and school age (7–15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs ratios. Furthermore, the correlations between the Parent-interview ASD Rating Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs were significantly higher in the ASD (7–15 years) than in TD (7–15 years). The PARS scores were significantly higher in the ASD and were significantly correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs ratios could be objective, measured indicators that could be used in clinical practice to assess stress in ASD children. |
format | Online Article Text |
id | pubmed-7244111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72441112020-06-03 Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential Morimoto, Masahito Hashimoto, Toshiaki Tsuda, Yoshimi Nakatsu, Tadanori Kitaoka, Taisuke Kyotani, Shojiro PLoS One Research Article There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 ASD children, samples were plasma. The subjects were divided into age groups: toddlers/preschool age (2–6 years) and school age (7–15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs ratios. Furthermore, the correlations between the Parent-interview ASD Rating Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs were significantly higher in the ASD (7–15 years) than in TD (7–15 years). The PARS scores were significantly higher in the ASD and were significantly correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs ratios could be objective, measured indicators that could be used in clinical practice to assess stress in ASD children. Public Library of Science 2020-05-22 /pmc/articles/PMC7244111/ /pubmed/32442231 http://dx.doi.org/10.1371/journal.pone.0233550 Text en © 2020 Morimoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Morimoto, Masahito Hashimoto, Toshiaki Tsuda, Yoshimi Nakatsu, Tadanori Kitaoka, Taisuke Kyotani, Shojiro Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title_full | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title_fullStr | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title_full_unstemmed | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title_short | Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
title_sort | assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244111/ https://www.ncbi.nlm.nih.gov/pubmed/32442231 http://dx.doi.org/10.1371/journal.pone.0233550 |
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