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Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli
Trans-4-hydroxy-l-proline is produced by trans-proline-4-hydroxylase with l-proline through glucose fermentation. Here, we designed a thorough “from A to Z” strategy to significantly improve trans-4-hydroxy-l-proline production. Through rare codon selected evolution, Escherichia coli M1 produced 18....
Autores principales: | Long, Mengfei, Xu, Meijuan, Ma, Zhenfeng, Pan, Xuewei, You, Jiajia, Hu, Mengkai, Shao, Yu, Yang, Taowei, Zhang, Xian, Rao, Zhiming |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244267/ https://www.ncbi.nlm.nih.gov/pubmed/32494747 http://dx.doi.org/10.1126/sciadv.aba2383 |
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