Cargando…

SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?

BACKGROUND: Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Li-rui, Li, Si-yu, Guo, Qiu-shi, Zhou, Wei, Zhang, Hong-mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244346/
https://www.ncbi.nlm.nih.gov/pubmed/32547193
http://dx.doi.org/10.2147/CMAR.S249754
_version_ 1783537557761425408
author Sun, Li-rui
Li, Si-yu
Guo, Qiu-shi
Zhou, Wei
Zhang, Hong-mei
author_facet Sun, Li-rui
Li, Si-yu
Guo, Qiu-shi
Zhou, Wei
Zhang, Hong-mei
author_sort Sun, Li-rui
collection PubMed
description BACKGROUND: Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices. CONCLUSION: SPOCK1 is a critical regulator of the ECM and mediates EMT in cancer cells. This suggests an important role for SPOCK1 in tumorigenesis, migration and invasion. SPOCK1 is a critical regulator of some processes involved in cancer progression, including cancer cell proliferation, apoptosis and migration. Herein, the functions of SPOCK1 in cancer progression are expounded, revealing the association between SPOCK1 and EMT in cancer metastasis. SPOCK1 is a positive downstream regulator of transforming growth factor-β, and SPOCK1-mediated EMT regulates invasion and metastasis through the Wnt/β-catenin pathway and PI3K/Akt signaling pathway. It is of significance that SPOCK1 may be an attractive prognostic biomarker and therapeutic target in cancer treatment.
format Online
Article
Text
id pubmed-7244346
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-72443462020-06-15 SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy? Sun, Li-rui Li, Si-yu Guo, Qiu-shi Zhou, Wei Zhang, Hong-mei Cancer Manag Res Review BACKGROUND: Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices. CONCLUSION: SPOCK1 is a critical regulator of the ECM and mediates EMT in cancer cells. This suggests an important role for SPOCK1 in tumorigenesis, migration and invasion. SPOCK1 is a critical regulator of some processes involved in cancer progression, including cancer cell proliferation, apoptosis and migration. Herein, the functions of SPOCK1 in cancer progression are expounded, revealing the association between SPOCK1 and EMT in cancer metastasis. SPOCK1 is a positive downstream regulator of transforming growth factor-β, and SPOCK1-mediated EMT regulates invasion and metastasis through the Wnt/β-catenin pathway and PI3K/Akt signaling pathway. It is of significance that SPOCK1 may be an attractive prognostic biomarker and therapeutic target in cancer treatment. Dove 2020-05-18 /pmc/articles/PMC7244346/ /pubmed/32547193 http://dx.doi.org/10.2147/CMAR.S249754 Text en © 2020 Sun et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Sun, Li-rui
Li, Si-yu
Guo, Qiu-shi
Zhou, Wei
Zhang, Hong-mei
SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title_full SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title_fullStr SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title_full_unstemmed SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title_short SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?
title_sort spock1 involvement in epithelial-to-mesenchymal transition: a new target in cancer therapy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244346/
https://www.ncbi.nlm.nih.gov/pubmed/32547193
http://dx.doi.org/10.2147/CMAR.S249754
work_keys_str_mv AT sunlirui spock1involvementinepithelialtomesenchymaltransitionanewtargetincancertherapy
AT lisiyu spock1involvementinepithelialtomesenchymaltransitionanewtargetincancertherapy
AT guoqiushi spock1involvementinepithelialtomesenchymaltransitionanewtargetincancertherapy
AT zhouwei spock1involvementinepithelialtomesenchymaltransitionanewtargetincancertherapy
AT zhanghongmei spock1involvementinepithelialtomesenchymaltransitionanewtargetincancertherapy