The acid–base and redox properties of menaquinone MK-4, MK-7, and MK-9 (vitamin K(2)) in DMPC monolayers on mercury

ABSTRACT: The acid–base and redox properties of the menaquinones MK-4, MK-7, and MK-9 (vitamin K(2)) have been studied in DMPC monolayers on mercury electrodes. The monolayers were prepared by adhesion-spreading of menaquinone-spiked DMPC liposomes on a stationary mercury drop electrode. All three m...

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Detalles Bibliográficos
Autores principales: Dharmaraj, Karuppasamy, Román Silva, Javier Ignacio, Kahlert, Heike, Lendeckel, Uwe, Scholz, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244470/
https://www.ncbi.nlm.nih.gov/pubmed/32372117
http://dx.doi.org/10.1007/s00249-020-01433-0
Descripción
Sumario:ABSTRACT: The acid–base and redox properties of the menaquinones MK-4, MK-7, and MK-9 (vitamin K(2)) have been studied in DMPC monolayers on mercury electrodes. The monolayers were prepared by adhesion-spreading of menaquinone-spiked DMPC liposomes on a stationary mercury drop electrode. All three menaquinones possess [Formula: see text] constants outside the experimentally accessible range, i.e., they are higher than about 12. The standard potentials of MK-4, MK-7, and MK-9 in the DMPC monolayers are very similar, i.e., 0.351, 0.326, and 0.330 V (corresponding to the biochemical standard potentials − 0.063, − 0.088, and − 0.085 V). GRAPHIC ABSTRACT: [Image: see text]

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