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A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia

The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural var...

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Autores principales: Ding, Junhua, Chen, Keliang, Liu, Haoming, Huang, Lin, Chen, Yan, Lv, Yingru, Yang, Qing, Guo, Qihao, Han, Zaizhu, Lambon Ralph, Matthew. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244491/
https://www.ncbi.nlm.nih.gov/pubmed/32444620
http://dx.doi.org/10.1038/s41467-020-16089-9
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author Ding, Junhua
Chen, Keliang
Liu, Haoming
Huang, Lin
Chen, Yan
Lv, Yingru
Yang, Qing
Guo, Qihao
Han, Zaizhu
Lambon Ralph, Matthew. A.
author_facet Ding, Junhua
Chen, Keliang
Liu, Haoming
Huang, Lin
Chen, Yan
Lv, Yingru
Yang, Qing
Guo, Qihao
Han, Zaizhu
Lambon Ralph, Matthew. A.
author_sort Ding, Junhua
collection PubMed
description The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and map these to the patients’ distribution of frontotemporal atrophy. Here we show that the degree of generalised semantic impairment is related to the patients’ total, bilateral ATL atrophy. Verbal production ability is related to total ATL atrophy as well as to the balance of left > right ATL atrophy. Apathy is found to relate positively to the degree of orbitofrontal atrophy. Disinhibition is related to right ATL and orbitofrontal atrophy, and face recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space.
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spelling pubmed-72444912020-06-03 A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia Ding, Junhua Chen, Keliang Liu, Haoming Huang, Lin Chen, Yan Lv, Yingru Yang, Qing Guo, Qihao Han, Zaizhu Lambon Ralph, Matthew. A. Nat Commun Article The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and map these to the patients’ distribution of frontotemporal atrophy. Here we show that the degree of generalised semantic impairment is related to the patients’ total, bilateral ATL atrophy. Verbal production ability is related to total ATL atrophy as well as to the balance of left > right ATL atrophy. Apathy is found to relate positively to the degree of orbitofrontal atrophy. Disinhibition is related to right ATL and orbitofrontal atrophy, and face recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space. Nature Publishing Group UK 2020-05-22 /pmc/articles/PMC7244491/ /pubmed/32444620 http://dx.doi.org/10.1038/s41467-020-16089-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ding, Junhua
Chen, Keliang
Liu, Haoming
Huang, Lin
Chen, Yan
Lv, Yingru
Yang, Qing
Guo, Qihao
Han, Zaizhu
Lambon Ralph, Matthew. A.
A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title_full A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title_fullStr A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title_full_unstemmed A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title_short A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
title_sort unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244491/
https://www.ncbi.nlm.nih.gov/pubmed/32444620
http://dx.doi.org/10.1038/s41467-020-16089-9
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