Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling

Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms underlying PLS3-dependent osteoporosis are understood. Of the over 20 identified osteoporosis-linked PLS3 mutations, we investigated...

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Detalles Bibliográficos
Autores principales: Schwebach, Christopher L., Kudryashova, Elena, Zheng, Weili, Orchard, Matthew, Smith, Harper, Runyan, Lucas A., Egelman, Edward H., Kudryashov, Dmitri S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244493/
https://www.ncbi.nlm.nih.gov/pubmed/32509377
http://dx.doi.org/10.1038/s41413-020-0095-2

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