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Relationship between headaches and tinnitus in a Swedish study

The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association betw...

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Autores principales: Lugo, Alessandra, Edvall, Niklas K., Lazar, Andra, Mehraei, Golbarg, Lopez-Escamez, Jose-Antonio, Bulla, Jan, Uhlen, Inger, Canlon, Barbara, Gallus, Silvano, Cederroth, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244494/
https://www.ncbi.nlm.nih.gov/pubmed/32444677
http://dx.doi.org/10.1038/s41598-020-65395-1
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author Lugo, Alessandra
Edvall, Niklas K.
Lazar, Andra
Mehraei, Golbarg
Lopez-Escamez, Jose-Antonio
Bulla, Jan
Uhlen, Inger
Canlon, Barbara
Gallus, Silvano
Cederroth, Christopher R.
author_facet Lugo, Alessandra
Edvall, Niklas K.
Lazar, Andra
Mehraei, Golbarg
Lopez-Escamez, Jose-Antonio
Bulla, Jan
Uhlen, Inger
Canlon, Barbara
Gallus, Silvano
Cederroth, Christopher R.
author_sort Lugo, Alessandra
collection PubMed
description The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.
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spelling pubmed-72444942020-05-30 Relationship between headaches and tinnitus in a Swedish study Lugo, Alessandra Edvall, Niklas K. Lazar, Andra Mehraei, Golbarg Lopez-Escamez, Jose-Antonio Bulla, Jan Uhlen, Inger Canlon, Barbara Gallus, Silvano Cederroth, Christopher R. Sci Rep Article The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity. Nature Publishing Group UK 2020-05-22 /pmc/articles/PMC7244494/ /pubmed/32444677 http://dx.doi.org/10.1038/s41598-020-65395-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lugo, Alessandra
Edvall, Niklas K.
Lazar, Andra
Mehraei, Golbarg
Lopez-Escamez, Jose-Antonio
Bulla, Jan
Uhlen, Inger
Canlon, Barbara
Gallus, Silvano
Cederroth, Christopher R.
Relationship between headaches and tinnitus in a Swedish study
title Relationship between headaches and tinnitus in a Swedish study
title_full Relationship between headaches and tinnitus in a Swedish study
title_fullStr Relationship between headaches and tinnitus in a Swedish study
title_full_unstemmed Relationship between headaches and tinnitus in a Swedish study
title_short Relationship between headaches and tinnitus in a Swedish study
title_sort relationship between headaches and tinnitus in a swedish study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244494/
https://www.ncbi.nlm.nih.gov/pubmed/32444677
http://dx.doi.org/10.1038/s41598-020-65395-1
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