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The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin

Metformin is the first-line treatment for type 2 diabetes. Inhibition of hepatic gluconeogenesis is the primary contributor to its anti-diabetic effect. Metformin inhibits complex I and α-glycerophosphate shuttle, and the resultant increase in cytoplasmic NADH/NAD(+) ratio diverts glucose precursors...

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Detalles Bibliográficos
Autores principales:	Kopel, Jonathan, Higuchi, Kei, Ristic, Bojana, Sato, Toshihiro, Ramachandran, Sabarish, Ganapathy, Vadivel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244496/ https://www.ncbi.nlm.nih.gov/pubmed/32444674 http://dx.doi.org/10.1038/s41598-020-65621-w

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