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Competitive ubiquitination activates the tumor suppressor p53

Blocking p53 ubiquitination through disrupting its interaction with MDM2 or inhibiting the MDM2 catalytic activity is the central mechanism by which the tumor suppressor p53 is activated in response to genotoxic challenges. Although MDM2 is first characterized as the major E3 ubiquitin ligase for p5...

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Detalles Bibliográficos
Autores principales:	Li, Xingyao, Guo, Mengqi, Cai, Lun, Du, Tingting, Liu, Ying, Ding, Han-Fei, Wang, Hongbo, Zhang, Junran, Chen, Xiaoguang, Yan, Chunhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244561/ https://www.ncbi.nlm.nih.gov/pubmed/31796886 http://dx.doi.org/10.1038/s41418-019-0463-x

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