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Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

Anti-Thy1.1 transgenic mice develop glomerular lesions that mimic collapsing focal segmental glomerulosclerosis (FSGS) in humans with collapse of the glomerular tuft and marked hyperplasia of the parietal epithelial cells (PECs). Immunostaining of phosphor-S6 ribosomal protein (pS6RP) revealed high...

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Detalles Bibliográficos
Autores principales:	Miesen, Laura, Eymael, Jennifer, Sharma, Shagun, Loeven, Markus A., Willemsen, Brigith, Bakker-van Bebber, Marinka, Mooren, Fieke, Meyer-Schwesinger, Catherine, Dijkman, Henry, Wetzels, Jack F. M., Jansen, Jitske, van der Vlag, Johan, Smeets, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244565/ https://www.ncbi.nlm.nih.gov/pubmed/32444668 http://dx.doi.org/10.1038/s41598-020-65352-y

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