Cargando…

The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

Epithelial ovarian cancer (EOC) is a highly lethal gynecologic malignancy arising from the fallopian tubes that has a high rate of chemoresistant recurrence and low five-year survival rate. The ovarian cancer biomarker HE4 is known to promote proliferation, metastasis, chemoresistance, and suppressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	James, Nicole E., Emerson, Jenna B., Borgstadt, Ashley D., Beffa, Lindsey, Oliver, Matthew T., Hovanesian, Virginia, Urh, Anze, Singh, Rakesh K., Rowswell-Turner, Rachael, DiSilvestro, Paul A., Ou, Joyce, Moore, Richard G., Ribeiro, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244765/ https://www.ncbi.nlm.nih.gov/pubmed/32444701 http://dx.doi.org/10.1038/s41598-020-65353-x

Ejemplares similares

Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes
por: James, Nicole E., et al.
Publicado: (2019)

HE4 (WFDC2) gene overexpression promotes ovarian tumor growth
por: Moore, Richard G., et al.
Publicado: (2014)

HE4 (WFDC2) Promotes Tumor Growth in Endometrial Cancer Cell Lines
por: Li, Jinping, et al.
Publicado: (2013)

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6
por: James, Nicole E., et al.
Publicado: (2019)

The similarities and differences between mesonephric carcinoma and mesonephric-like carcinoma: Two cases
por: Kulkarni, Amita, et al.
Publicado: (2021)

WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung
por: Bingle, Lynne, et al.
Publicado: (2006)

Increased levels of HE4 (WFDC2) in systemic sclerosis: a novel biomarker reflecting interstitial lung disease severity?
por: Zhang, Mingxia, et al.
Publicado: (2020)

Modulated expression of WFDC1 during carcinogenesis and cellular senescence
por: Madar, Shalom, et al.
Publicado: (2009)

WFDC Protein: A Promising Diagnosis Biomarker of Ovarian Cancer
por: Zhang, Chen, et al.
Publicado: (2021)

WFDC21P promotes triple-negative breast cancer proliferation and migration through WFDC21P/miR-628/SMAD3 axis
por: Wei, Yu-Bo, et al.
Publicado: (2022)

WFDC2 suppresses prostate cancer metastasis by modulating EGFR signaling inactivation
por: Xiong, Yaoyi, et al.
Publicado: (2020)

A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression
por: James, Nicole E., et al.
Publicado: (2022)

Intratumoral expression analysis reveals that OX40 and TIM-3 are prominently expressed and have variable associations with clinical outcomes in high grade serous ovarian cancer
por: James, Nicole E., et al.
Publicado: (2022)

Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity
Publicado: (2014)

Sequence Diversity of Pan troglodytes Subspecies and the Impact of WFDC6 Selective Constraints in Reproductive Immunity
por: Ferreira, Zélia, et al.
Publicado: (2013)

Characterisation of urinary WFDC12 in small nocturnal basal primates, mouse lemurs (Microcebus spp.)
por: Unsworth, Jennifer, et al.
Publicado: (2017)

Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis
por: Guan, Yun-feng, et al.
Publicado: (2020)

Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma
por: Li, Junfeng, et al.
Publicado: (2023)

COL1A1-PDGFB fusion uterine fibrosarcoma: A case report with treatment implication
por: Grindstaff, Samuel L., et al.
Publicado: (2019)

WFDC2 contributes to epithelial–mesenchymal transition (EMT) by activating AKT signaling pathway and regulating MMP-2 expression
por: Chen, Yao, et al.
Publicado: (2019)

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease
por: Zhao, Fulei, et al.
Publicado: (2022)

WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation
por: Li, Guolin, et al.
Publicado: (2023)

WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer
por: Liu, Tianqi, et al.
Publicado: (2023)

Aldehyde Dehydrogenase 1A1: Friend or Foe to Female Metabolism?
por: Petrosino, Jennifer M., et al.
Publicado: (2014)

WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cells
por: Chen, Yao, et al.
Publicado: (2016)

WFDC1/ps20: A host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection
por: Rogers, Erin, et al.
Publicado: (2012)

WFDC2 Contributes to Epithelial–Mesenchymal Transition (EMT) by Activating AKT Signaling Pathway and Regulating MMP-2 Expression [Retraction]
Publicado: (2022)

COL1A1-PDGFB fusion uterine sarcoma and its response to Imatinib therapy
por: Grindstaff, Samuel L., et al.
Publicado: (2020)

Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins
por: James, Nicole E., et al.
Publicado: (2019)

A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer
por: Cui, Huaiping, et al.
Publicado: (2021)

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people
por: DiSilvestro, Robert A, et al.
Publicado: (2012)

A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people
por: DiSilvestro, Robert A., et al.
Publicado: (2015)

Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer
por: Vetsika, Eleni-Kyriaki, et al.
Publicado: (2019)

Soy versus whey protein bars: Effects on exercise training impact on lean body mass and antioxidant status
por: Brown, Erin C, et al.
Publicado: (2004)

Chemoimmunotherapy as long-term maintenance therapy for cancer
por: Egilmez, Nejat K., et al.
Publicado: (2012)

Comparison of Angiogenic, Cytoprotective, and Immunosuppressive Properties of Human Amnion- and Chorion-Derived Mesenchymal Stem Cells
por: Yamahara, Kenichi, et al.
Publicado: (2014)

Myeloid-derived suppressor cell and macrophage exert distinct angiogenic and immunosuppressive effects in breast cancer
por: Fang, Zhaoxu, et al.
Publicado: (2017)

WFDC1 expression identifies memory CD4 T- lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions
por: Alvarez, Raymond A, et al.
Publicado: (2011)

Expression of two WFDC1/ps20 isoforms in prostate stromal cells induces paracrine apoptosis through regulation of PTGS2/COX-2
por: Hickman, Oliver J, et al.
Publicado: (2016)

miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation
por: Zhang, Qian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_htfs53rh1en6j7uqn0g92404o9