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MitraClip(®) as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report

BACKGROUND: Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regur...

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Detalles Bibliográficos
Autores principales: Vasquez-Rodríguez, Juan Felipe, Medina, Héctor Manuel, Cabrales, Jaime Ramón, Torres, Adriana Gisella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245051/
https://www.ncbi.nlm.nih.gov/pubmed/32467867
http://dx.doi.org/10.1093/ehjcr/ytz238
Descripción
Sumario:BACKGROUND: Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regurgitation, which is present in many cardiopathies like end-stage Chagasic cardiomyopathy. CASE SUMMARY: We present a case of a young man with end-stage heart failure secondary to Chagas cardiomyopathy with severe functional mitral regurgitation (FMR) and severe PH. The patient received percutaneous correction with MitraClip® system reducing PH and making him a suitable candidate for heart transplant. DISCUSSION: In patients with advanced heart failure, FMR, and severe PH, optimal treatment according to current guide lines is recommended. MitraClip(®) therapy appears to be safe and effective for control of severe PH as a bridge measure for cardiac transplantation.