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Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch

Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In mammals, PER2 protein abundance is regulated by CK1-mediated phosphorylation and proteasomal degradation. On the other hand, recent studies have questioned whether the degradation of the core circadian mac...

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Detalles Bibliográficos
Autores principales:	Masuda, Shusaku, Narasimamurthy, Rajesh, Yoshitane, Hikari, Kim, Jae Kyoung, Fukada, Yoshitaka, Virshup, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245125/ https://www.ncbi.nlm.nih.gov/pubmed/32354999 http://dx.doi.org/10.1073/pnas.2000266117

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