Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5′ mRNA Stem–Loop and Enhanced Drop-off

Efficient translational bypassing of a 50-nt non-coding gap in a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals. Here we investigate the function of the mRNA stem–loop 5′ of the take-off codon, as well as the importance of ribosome loading density on the mRNA for effici...

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Detalles Bibliográficos
Autores principales: O'Loughlin, Sinéad, Capece, Mark C., Klimova, Mariia, Wills, Norma M., Coakley, Arthur, Samatova, Ekaterina, O'Connor, Patrick B.F., Loughran, Gary, Weissman, Jonathan S., Baranov, Pavel V., Rodnina, Marina V., Puglisi, Joseph D., Atkins, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245268/
https://www.ncbi.nlm.nih.gov/pubmed/32454154
http://dx.doi.org/10.1016/j.jmb.2020.05.010

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