Cargando…

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

OBJECTIVE: To determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI. RESEARCH DESIGN AND METHODS: We randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Jagdeep S.S., Mordi, Ify R., Vickneson, Keeran, Fathi, Amir, Donnan, Peter T., Mohan, Mohapradeep, Choy, Anna Maria J., Gandy, Stephen, George, Jacob, Khan, Faisel, Pearson, Ewan R., Houston, J. Graeme, Struthers, Allan D., Lang, Chim C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Novel Communications in Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245350/ https://www.ncbi.nlm.nih.gov/pubmed/32245746 http://dx.doi.org/10.2337/dc19-2187

Ejemplares similares

Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design
por: Singh, Jagdeep S. S., et al.
Publicado: (2016)

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial
por: Mohan, Mohapradeep, et al.
Publicado: (2019)

SGLT2-inhibitors; more than just glycosuria and diuresis
por: Fathi, Amir, et al.
Publicado: (2020)

Left Ventricular Hypertrophy in Diabetic Cardiomyopathy: A Target for Intervention
por: Mohan, Mohapradeep, et al.
Publicado: (2021)

Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial
por: Persson, Frederik, et al.
Publicado: (2021)

A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial
por: Brown, Alexander J M, et al.
Publicado: (2020)

Renal and Cardiovascular Effects of sodium–glucose cotransporter 2 (SGLT2) inhibition in combination with loop Diuretics in diabetic patients with Chronic Heart Failure (RECEDE-CHF): protocol for a randomised controlled double-blind cross-over trial
por: Mordi, Natalie A, et al.
Publicado: (2017)

Renal and Cardiovascular Effects of SGLT2 Inhibition in Combination With Loop Diuretics in Patients With Type 2 Diabetes and Chronic Heart Failure: The RECEDE-CHF Trial
por: Mordi, Natalie A., et al.
Publicado: (2020)

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension
por: Gingles, Christopher R., et al.
Publicado: (2019)

Hospital readmissions for patients with prostate cancer are higher after radiotherapy than after prostatectomy
por: Kesavan, Arshvin, et al.
Publicado: (2022)

Efficacy of noninvasive cardiac imaging tests in diagnosis and management of stable coronary artery disease
por: Mordi, Ify R, et al.
Publicado: (2017)

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure
por: Steggall, Abbey, et al.
Publicado: (2017)

Inflammation as a therapeutic target in heart failure with preserved ejection fraction
por: Peh, Zhen Hui, et al.
Publicado: (2023)

Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study
por: Brown, Alexander J.M., et al.
Publicado: (2017)

Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes
por: Al-Talabany, Shaween, et al.
Publicado: (2018)

Dapagliflozin: Cardiovascular Safety and Benefits in Type 2 Diabetes Mellitus
por: Saleem, Fatima
Publicado: (2017)

Type 2 Diabetes, Metabolic Traits, and Risk of Heart Failure: A Mendelian Randomization Study
por: Mordi, Ify R., et al.
Publicado: (2021)

Evolution of Abnormal Plasma Glucagon Responses to Mixed-Meal Feedings in Youth With Type 1 Diabetes During the First 2 Years After Diagnosis
por: Sherr, Jennifer, et al.
Publicado: (2014)

Early Hyperglycemia Detected by Continuous Glucose Monitoring in Children at Risk for Type 1 Diabetes
por: Steck, Andrea K., et al.
Publicado: (2014)

Corneal Confocal Microscopy Detects Neuropathy in Subjects With Impaired Glucose Tolerance
por: Asghar, Omar, et al.
Publicado: (2014)

Real-Time Continuous Glucose Monitoring Significantly Reduces Severe Hypoglycemia in Hypoglycemia-Unaware Patients With Type 1 Diabetes
por: Choudhary, Pratik, et al.
Publicado: (2013)

Novel Use and Utility of Integrated Electronic Health Records to Assess Rates of Prediabetes Recognition and Treatment: Brief Report From an Integrated Electronic Health Records Pilot Study
por: Schmittdiel, Julie A., et al.
Publicado: (2014)

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes
por: Kemppainen, Kaisa M., et al.
Publicado: (2015)

Testing for Rewards: A Pilot Study to Improve Type 1 Diabetes Management in Adolescents
por: Petry, Nancy M., et al.
Publicado: (2015)

Impact of Lowering BMI Cut Points as Recommended in the Revised American Diabetes Association's Standards of Medical Care in Diabetes—2015 on Diabetes Screening in Asian Americans
por: Hsia, Daniel S., et al.
Publicado: (2015)

Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance
por: Ghosh, Pamela, et al.
Publicado: (2017)

Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?
por: Ferrara, Christine Therese, et al.
Publicado: (2017)

Anti–PD-1 Therapy–Associated Type 1 Diabetes in a Pediatric Patient With Relapsed Classical Hodgkin Lymphoma
por: Samoa, Raynald A., et al.
Publicado: (2020)

Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the MTNR1B Gene
por: Tan, Xiao, et al.
Publicado: (2020)

Glucose as the Fifth Vital Sign: A Randomized Controlled Trial of Continuous Glucose Monitoring in a Non-ICU Hospital Setting
por: Fortmann, Addie L., et al.
Publicado: (2020)

Natural Language Processing Improves Detection of Nonsevere Hypoglycemia in Medical Records Versus Coding Alone in Patients With Type 2 Diabetes but Does Not Improve Prediction of Severe Hypoglycemia Events: An Analysis Using the Electronic Medical Record in a Large Health System
por: Misra-Hebert, Anita D., et al.
Publicado: (2020)

Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes
por: Šuput Omladič, Jasna, et al.
Publicado: (2020)

Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes
por: Misra, Shivani, et al.
Publicado: (2020)

Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S.
por: Garrett, Timothy J., et al.
Publicado: (2020)

Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes
por: Hartman, Mark L., et al.
Publicado: (2020)

Evaluation of Factors Related to Glycemic Management in Professional Cyclists With Type 1 Diabetes Over a 7-Day Stage Race
por: Scott, Sam N., et al.
Publicado: (2020)

Continuous Glucose Monitoring in the Intensive Care Unit During the COVID-19 Pandemic
por: Agarwal, Shivani, et al.
Publicado: (2021)

Remote Continuous Glucose Monitoring With a Computerized Insulin Infusion Protocol for Critically Ill Patients in a COVID-19 Medical ICU: Proof of Concept
por: Davis, Georgia M., et al.
Publicado: (2021)

Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
por: Hu, Yun, et al.
Publicado: (2021)

Carbohydrate Requirements for Prolonged, Fasted Exercise With and Without Basal Rate Reductions in Adults With Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion
por: McGaugh, Sarah M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vi22sqet40m7qvkf54hf7pn4bm