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Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review

Breast cancer remains as a concerning global health issue, being the second leading cause of cancer deaths among women in the United States (US) in 2019. Therefore, there is an urgent and substantial need to explore novel strategies to combat breast cancer. A potential solution may come from the use...

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Autores principales: Saravanan, Muthupandian, Vahidi, Hossein, Medina Cruz, David, Vernet-Crua, Ada, Mostafavi, Ebrahim, Stelmach, Ryan, Webster, Thomas J, Mahjoub, Mohammad Ali, Rashedi, Masoumeh, Barabadi, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245458/
https://www.ncbi.nlm.nih.gov/pubmed/32547015
http://dx.doi.org/10.2147/IJN.S240293
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author Saravanan, Muthupandian
Vahidi, Hossein
Medina Cruz, David
Vernet-Crua, Ada
Mostafavi, Ebrahim
Stelmach, Ryan
Webster, Thomas J
Mahjoub, Mohammad Ali
Rashedi, Masoumeh
Barabadi, Hamed
author_facet Saravanan, Muthupandian
Vahidi, Hossein
Medina Cruz, David
Vernet-Crua, Ada
Mostafavi, Ebrahim
Stelmach, Ryan
Webster, Thomas J
Mahjoub, Mohammad Ali
Rashedi, Masoumeh
Barabadi, Hamed
author_sort Saravanan, Muthupandian
collection PubMed
description Breast cancer remains as a concerning global health issue, being the second leading cause of cancer deaths among women in the United States (US) in 2019. Therefore, there is an urgent and substantial need to explore novel strategies to combat breast cancer. A potential solution may come from the use of cancer nanotechnology, an innovative field of study which investigates the potential of nanomaterials for cancer diagnosis, therapy, and theranostic applications. Consequently, the theranostic functionality of cancer nanotechnology has been gaining much attention between scientists during the past few years and is growing exponentially. The use of biosynthesized gold nanoparticles (AuNPs) has been explored as an efficient mechanism for the treatment of breast cancer. The present study supposed a global systematic review to evaluate the effectiveness of biogenic AuNPs for the treatment of breast cancer and their anticancer molecular mechanisms through in vitro studies. Online electronic databases, including Cochrane, PubMed, Scopus, Web of Science, Science Direct, ProQuest, and Embase, were searched for the articles published up to July 16, 2019. Our findings revealed that plant-mediated synthesis was the most common approach for the generation of AuNPs. Most of the studies reported spherical or nearly spherical-shaped AuNPs with a mean diameter less than 100 nm in size. A significantly larger cytotoxicity was observed when the biogenic AuNPs were tested towards breast cancer cells compared to healthy cells. Moreover, biogenic AuNPs demonstrated significant synergistic activity in combination with other anticancer drugs through in vitro studies. Although we provided strong and comprehensive preliminary in vitro data, further in vivo investigations are required to show the reliability and efficacy of these NPs in animal models.
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spelling pubmed-72454582020-06-15 Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review Saravanan, Muthupandian Vahidi, Hossein Medina Cruz, David Vernet-Crua, Ada Mostafavi, Ebrahim Stelmach, Ryan Webster, Thomas J Mahjoub, Mohammad Ali Rashedi, Masoumeh Barabadi, Hamed Int J Nanomedicine Review Breast cancer remains as a concerning global health issue, being the second leading cause of cancer deaths among women in the United States (US) in 2019. Therefore, there is an urgent and substantial need to explore novel strategies to combat breast cancer. A potential solution may come from the use of cancer nanotechnology, an innovative field of study which investigates the potential of nanomaterials for cancer diagnosis, therapy, and theranostic applications. Consequently, the theranostic functionality of cancer nanotechnology has been gaining much attention between scientists during the past few years and is growing exponentially. The use of biosynthesized gold nanoparticles (AuNPs) has been explored as an efficient mechanism for the treatment of breast cancer. The present study supposed a global systematic review to evaluate the effectiveness of biogenic AuNPs for the treatment of breast cancer and their anticancer molecular mechanisms through in vitro studies. Online electronic databases, including Cochrane, PubMed, Scopus, Web of Science, Science Direct, ProQuest, and Embase, were searched for the articles published up to July 16, 2019. Our findings revealed that plant-mediated synthesis was the most common approach for the generation of AuNPs. Most of the studies reported spherical or nearly spherical-shaped AuNPs with a mean diameter less than 100 nm in size. A significantly larger cytotoxicity was observed when the biogenic AuNPs were tested towards breast cancer cells compared to healthy cells. Moreover, biogenic AuNPs demonstrated significant synergistic activity in combination with other anticancer drugs through in vitro studies. Although we provided strong and comprehensive preliminary in vitro data, further in vivo investigations are required to show the reliability and efficacy of these NPs in animal models. Dove 2020-05-19 /pmc/articles/PMC7245458/ /pubmed/32547015 http://dx.doi.org/10.2147/IJN.S240293 Text en © 2020 Saravanan et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Saravanan, Muthupandian
Vahidi, Hossein
Medina Cruz, David
Vernet-Crua, Ada
Mostafavi, Ebrahim
Stelmach, Ryan
Webster, Thomas J
Mahjoub, Mohammad Ali
Rashedi, Masoumeh
Barabadi, Hamed
Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title_full Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title_fullStr Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title_full_unstemmed Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title_short Emerging Antineoplastic Biogenic Gold Nanomaterials for Breast Cancer Therapeutics: A Systematic Review
title_sort emerging antineoplastic biogenic gold nanomaterials for breast cancer therapeutics: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245458/
https://www.ncbi.nlm.nih.gov/pubmed/32547015
http://dx.doi.org/10.2147/IJN.S240293
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