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HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life

PURPOSE: HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. MATERIAL AND METHODS: Fifty-two HIV+ patients with HPV-associated anal lesions were enrolle...

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Autores principales: Wesselmann, Paul, Schwarze-Zander, Carolynne, Boesecke, Christoph, Rockstroh, Jürgen, Stoffels, B., Vilz, Tim O., Glowka, Tim R., Kalff, J. C., von Websky, Martin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245587/
https://www.ncbi.nlm.nih.gov/pubmed/32215680
http://dx.doi.org/10.1007/s00384-020-03567-1
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author Wesselmann, Paul
Schwarze-Zander, Carolynne
Boesecke, Christoph
Rockstroh, Jürgen
Stoffels, B.
Vilz, Tim O.
Glowka, Tim R.
Kalff, J. C.
von Websky, Martin W.
author_facet Wesselmann, Paul
Schwarze-Zander, Carolynne
Boesecke, Christoph
Rockstroh, Jürgen
Stoffels, B.
Vilz, Tim O.
Glowka, Tim R.
Kalff, J. C.
von Websky, Martin W.
author_sort Wesselmann, Paul
collection PubMed
description PURPOSE: HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. MATERIAL AND METHODS: Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004–11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires. RESULTS: Fifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032). CONCLUSION: HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00384-020-03567-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-72455872020-06-03 HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life Wesselmann, Paul Schwarze-Zander, Carolynne Boesecke, Christoph Rockstroh, Jürgen Stoffels, B. Vilz, Tim O. Glowka, Tim R. Kalff, J. C. von Websky, Martin W. Int J Colorectal Dis Original Article PURPOSE: HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. MATERIAL AND METHODS: Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004–11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires. RESULTS: Fifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032). CONCLUSION: HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00384-020-03567-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-03-26 2020 /pmc/articles/PMC7245587/ /pubmed/32215680 http://dx.doi.org/10.1007/s00384-020-03567-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Wesselmann, Paul
Schwarze-Zander, Carolynne
Boesecke, Christoph
Rockstroh, Jürgen
Stoffels, B.
Vilz, Tim O.
Glowka, Tim R.
Kalff, J. C.
von Websky, Martin W.
HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title_full HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title_fullStr HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title_full_unstemmed HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title_short HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
title_sort hpv-associated anal lesions in hiv+ patients: long-term results regarding quality of life
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245587/
https://www.ncbi.nlm.nih.gov/pubmed/32215680
http://dx.doi.org/10.1007/s00384-020-03567-1
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