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Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis
BACKGROUND: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population. OBJECTIVE: To compare COVID-19 trends among people with and without IDD, overall and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245650/ https://www.ncbi.nlm.nih.gov/pubmed/32473875 http://dx.doi.org/10.1016/j.dhjo.2020.100942 |
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author | Turk, Margaret A. Landes, Scott D. Formica, Margaret K. Goss, Katherine D. |
author_facet | Turk, Margaret A. Landes, Scott D. Formica, Margaret K. Goss, Katherine D. |
author_sort | Turk, Margaret A. |
collection | PubMed |
description | BACKGROUND: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population. OBJECTIVE: To compare COVID-19 trends among people with and without IDD, overall and stratified by age. METHODS: Data from the TriNetX COVID-19 Research Network platform was used to identify COVID-19 patients. Analysis focused on trends in comorbidities, number of cases, number of deaths, and case-fatality rate among patients with and without IDD who had a positive diagnosis for COVID-19 through May 14, 2020. RESULTS: People with IDD had higher prevalence of specific comorbidities associated with poorer COVID-19 outcomes. Distinct age-related differences in COVID-19 trends were present among those with IDD, with a higher concentration of COVID-19 cases at younger ages. In addition, while the overall case-fatality rate was similar for those with IDD (5.1%) and without IDD (5.4%), these rates differed by age: ages ≤17 – IDD 1.6%, without IDD <0.01%; ages 18–74 – IDD 4.5%, without IDD 2.7%; ages ≥75– IDD 21.1%, without IDD, 20.7%. CONCLUSIONS: Though of concern for all individuals, COVID-19 appears to present a greater risk to people with IDD, especially at younger ages. Future research should seek to document COVID-19 trends among people with IDD, with particular attention to age related trends. |
format | Online Article Text |
id | pubmed-7245650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72456502020-05-26 Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis Turk, Margaret A. Landes, Scott D. Formica, Margaret K. Goss, Katherine D. Disabil Health J Article BACKGROUND: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population. OBJECTIVE: To compare COVID-19 trends among people with and without IDD, overall and stratified by age. METHODS: Data from the TriNetX COVID-19 Research Network platform was used to identify COVID-19 patients. Analysis focused on trends in comorbidities, number of cases, number of deaths, and case-fatality rate among patients with and without IDD who had a positive diagnosis for COVID-19 through May 14, 2020. RESULTS: People with IDD had higher prevalence of specific comorbidities associated with poorer COVID-19 outcomes. Distinct age-related differences in COVID-19 trends were present among those with IDD, with a higher concentration of COVID-19 cases at younger ages. In addition, while the overall case-fatality rate was similar for those with IDD (5.1%) and without IDD (5.4%), these rates differed by age: ages ≤17 – IDD 1.6%, without IDD <0.01%; ages 18–74 – IDD 4.5%, without IDD 2.7%; ages ≥75– IDD 21.1%, without IDD, 20.7%. CONCLUSIONS: Though of concern for all individuals, COVID-19 appears to present a greater risk to people with IDD, especially at younger ages. Future research should seek to document COVID-19 trends among people with IDD, with particular attention to age related trends. Elsevier Inc. 2020-07 2020-05-24 /pmc/articles/PMC7245650/ /pubmed/32473875 http://dx.doi.org/10.1016/j.dhjo.2020.100942 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Turk, Margaret A. Landes, Scott D. Formica, Margaret K. Goss, Katherine D. Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title | Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title_full | Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title_fullStr | Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title_full_unstemmed | Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title_short | Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis |
title_sort | intellectual and developmental disability and covid-19 case-fatality trends: trinetx analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245650/ https://www.ncbi.nlm.nih.gov/pubmed/32473875 http://dx.doi.org/10.1016/j.dhjo.2020.100942 |
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