Cargando…

Elucidation of the Molecular Mechanisms Underlying Sorafenib-Induced Hepatotoxicity

Sorafenib is a small, orally-active multikinase inhibitor that is most frequently used for the management of renal cell carcinoma, hepatocellular carcinoma, and radioactive iodine-resistant thyroid carcinoma. However, recent reports have associated sorafenib with hepatotoxicity that can limit its cl...

Descripción completa

Detalles Bibliográficos
Autores principales:	AlAsmari, Abdullah F., Ali, Nemat, AlAsmari, Fawaz, AlAnazi, Wael A., Alqahtani, Faleh, Alharbi, Metab, Alotaibi, Farraj M., Aldossari, Abdullah A., AlSwayyed, Mohammed, Alanazi, Mohammed M., Alshamrani, Ali A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245685/ https://www.ncbi.nlm.nih.gov/pubmed/32509153 http://dx.doi.org/10.1155/2020/7453406

Ejemplares similares

Protective effect of diosmin against doxorubicin-induced nephrotoxicity
por: Ali, Nemat, et al.
Publicado: (2021)

Geraniol Ameliorates Doxorubicin-Mediated Kidney Injury through Alteration of Antioxidant Status, Inflammation, and Apoptosis: Potential Roles of NF-κB and Nrf2/Ho-1
por: AlAsmari, Abdullah F., et al.
Publicado: (2022)

Liraglutide attenuates gefitinib-induced cardiotoxicity and promotes cardioprotection through the regulation of MAPK/NF-κB signaling pathways
por: AlAsmari, Abdullah F., et al.
Publicado: (2020)

Venetoclax Induces Cardiotoxicity through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-κB and BCL-2 Pathway
por: AlAsmari, Abdullah F., et al.
Publicado: (2022)

Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study
por: AlAsmari, Abdullah F., et al.
Publicado: (2021)

Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation
por: Ali, Nemat, et al.
Publicado: (2021)

Exploring the promising application of Be(12)O(12) nanocage for the abatement of paracetamol using DFT simulations
por: Gul, Sana, et al.
Publicado: (2023)

Ameliorative effect of vanillin on scopolamine-induced dementia-like cognitive impairment in a mouse model
por: Anand, Abhinav, et al.
Publicado: (2022)

Angiotensin II type 1 receptor blockade attenuates gefitinib-induced cardiac hypertrophy via adjusting angiotensin II-mediated oxidative stress and JNK/P38 MAPK pathway in a rat model
por: Alanazi, Wael A., et al.
Publicado: (2022)

In silico investigations of heparin binding to SARS‐CoV‐2 variants with a focus at the RBD/ACE2 interface
por: Ali, Nemat, et al.
Publicado: (2022)

Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams
por: Alasmari, Fawaz, et al.
Publicado: (2023)

Synthesis, molecular structure and urease inhibitory activity of novel bis-Schiff bases of benzyl phenyl ketone: A combined theoretical and experimental approach
por: Ahmad, Rashid, et al.
Publicado: (2023)

GNL3 and PA2G4 as Prognostic Biomarkers in Prostate Cancer
por: Kumar, Shashank, et al.
Publicado: (2023)

Angiotensin II receptor Neprilysin inhibitor (LCZ696) compared to Valsartan attenuates Hepatotoxicity in STZ-induced hyperglycemic rats
por: Alqahtani, Faleh, et al.
Publicado: (2020)

Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases
por: Rasool, Muhammad F., et al.
Publicado: (2021)

Consequential Impact of Particulate Matter Linked Inter-Fibrillar Mitochondrial Dysfunction in Rat Myocardium Subjected to Ischemia Reperfusion Injury
por: Sivakumar, Bhavana, et al.
Publicado: (2022)

Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective
por: Prasad, Kartikay, et al.
Publicado: (2020)

Targeting DNA methylation can reduce cardiac injury associated with ischemia reperfusion: One step closer to clinical translation with blood-borne assessment
por: Boovarahan, Sri Rahavi, et al.
Publicado: (2022)

Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS
por: Alasmari, Fawaz, et al.
Publicado: (2022)

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder
por: Alasmari, Fawaz, et al.
Publicado: (2022)

Structure Elucidation and Interaction Dynamics of MefA-MsrD Efflux Proteins in Streptococcus pneumoniae: Impact on Macrolide Susceptibility
por: Peela, Sreeram Chandra Murthy, et al.
Publicado: (2023)

Investigating Chaperone like Activity of Green Silver Nanoparticles: Possible Implications in Drug Development
por: Rauf, Mohd Ahmar, et al.
Publicado: (2022)

Age-associated global DNA hypermethylation augments the sensitivity of hearts towards ischemia-reperfusion injury
por: Boovarahan, Sri Rahavi, et al.
Publicado: (2022)

Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications
por: Zaman, Muhammad, et al.
Publicado: (2021)

Non-pharmacological Interventions for Intractable Epilepsy
por: Alqahtani, Faleh, et al.
Publicado: (2020)

DOE-Assisted Formulation, Optimization, and Characterization of Tioconazole-Loaded Transferosomal Hydrogel for the Effective Treatment of Atopic Dermatitis: In Vitro and In Vivo Evaluation
por: Kharwade, Rohini, et al.
Publicado: (2023)

Patterns of Response to Different Treatment Strategies in Seropositive Rheumatoid Arthritis Patients in a Tertiary Hospital in South‐Western Saudi Arabia: A Retrospective Study
por: AlOmair, Mohammed, et al.
Publicado: (2021)

Twenty-five year-old female with sudden onset itchy skin eruption over her upper back and chest three weeks after starting a ketogenic diet
por: Alkeraye, Salim, et al.
Publicado: (2019)

Supplementation of Morin Restores the Altered Bone Histomorphometry in Hyperglycemic Rodents via Regulation of Insulin/IGF-1 Signaling
por: Abuohashish, Hatem M., et al.
Publicado: (2021)

Synthesis, Antioxidant, Molecular Docking and DNA Interaction Studies of Metal-Based Imine Derivatives
por: Ibrahim, Mohammad, et al.
Publicado: (2023)

Diabetic Hearts Exhibit Global DNA Hypermethylation That Alter the Mitochondrial Functional Genes to Enhance the Sensitivity of the Heart to Ischemia Reperfusion Injury
por: Boovarahan, Sri Rahavi, et al.
Publicado: (2022)

Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations
por: Alasmari, Mohammed S., et al.
Publicado: (2022)

Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study
por: Ahmad, Sajjad, et al.
Publicado: (2023)

Valsartan prevents gefitinib-induced lung inflammation, oxidative stress, and alteration of plasma metabolites in rats
por: Alanazi, Wael A., et al.
Publicado: (2023)

Triethylammonium salt of a synthesized dicoumarol: Structural insight and human anti-glioblastoma activities
por: Khan, Afzal, et al.
Publicado: (2023)

Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities
por: Javaid, Sana, et al.
Publicado: (2021)

Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurobehaviors and Pre/Postsynaptic Neuron Markers
por: Alasmari, Fawaz, et al.
Publicado: (2022)

A pH-responsive bi-MIL-88B MOF coated with folic acid-conjugated chitosan as a promising nanocarrier for targeted drug delivery of 5-Fluorouracil
por: Akbar, Muhammad Usman, et al.
Publicado: (2023)

Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients
por: Alasmari, Fawaz, et al.
Publicado: (2021)

Factors Affecting Glycemic Control among Saudi Children with Type 1 Diabetes Mellitus in Aseer Region, Southwestern Saudi Arabia
por: Al-Qahtani, Saleh M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_imndbh060anfj5s72s7pt8nd7h