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Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19

BACKGROUND: Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by the new coronavirus. Previous studies have shown that the chest CT examination plays an important role in the diagnosis and monitoring of COVID-19. However, some patients with COVID-19 had low white blood cell c...

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Autores principales: Li, Jiawei, Wang, Xiao, Huang, Xiaolu, Chen, Fangxing, Zhang, Xuesong, Liu, Ying, Luo, Guangzuo, Xu, Xunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245769/
https://www.ncbi.nlm.nih.gov/pubmed/32448136
http://dx.doi.org/10.1186/s12880-020-00456-5
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author Li, Jiawei
Wang, Xiao
Huang, Xiaolu
Chen, Fangxing
Zhang, Xuesong
Liu, Ying
Luo, Guangzuo
Xu, Xunhua
author_facet Li, Jiawei
Wang, Xiao
Huang, Xiaolu
Chen, Fangxing
Zhang, Xuesong
Liu, Ying
Luo, Guangzuo
Xu, Xunhua
author_sort Li, Jiawei
collection PubMed
description BACKGROUND: Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by the new coronavirus. Previous studies have shown that the chest CT examination plays an important role in the diagnosis and monitoring of COVID-19. However, some patients with COVID-19 had low white blood cell counts and reduced lymphocyte ratios. Multiple CT examinations may cause radiation damages as well as increase the apoptosis of peripheral blood lymphocytes. A new low-dose CT method should be developed because the regular CT may aggravate the disease. METHOD: Sixty cases were randomly divided into the study group (n = 30) and control group (n = 30). The lung window was reconstructed by Karl 3D iterative technique in the study group. The image quality was subjectively evaluated by two senior chest group diagnostic physicians using a 5-point double-blind method. The value of CT measurement and its standard deviation (SD) was used as an objective evaluation criteria. The volume of CT dose index (CTDI(vol)), dose length product (DLP) and effective dose (ED) from the two groups were compared and analyzed statistically. RESULT: There was no significant difference in the occurrence rates of ground glass opacities, consolidation, crazy-paving pattern, fiber cable shadow and axial interstitial thickening between the study group and control group (p > 0.05). In addition, no significant difference was found for the subjective score of overall image quality and image noise level (SD) between the two groups (p > 0.05). However, significant differences was found in CTDI(vol), DLP, and ED between the study group and the control group (p < 0.05). The effective dose of the study group was reduced by 76% compared to the control group. CONCLUSION: CareDose 4D low-dose scanning combined with Karl 3D iterative reconstruction technology can not only greatly reduce the radiation dose, but also provide images that meet the diagnostic criteria of COVID-19, which can be used as a routine method for the follow-up of COVID-19 patients.
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spelling pubmed-72457692020-05-26 Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19 Li, Jiawei Wang, Xiao Huang, Xiaolu Chen, Fangxing Zhang, Xuesong Liu, Ying Luo, Guangzuo Xu, Xunhua BMC Med Imaging Research Article BACKGROUND: Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by the new coronavirus. Previous studies have shown that the chest CT examination plays an important role in the diagnosis and monitoring of COVID-19. However, some patients with COVID-19 had low white blood cell counts and reduced lymphocyte ratios. Multiple CT examinations may cause radiation damages as well as increase the apoptosis of peripheral blood lymphocytes. A new low-dose CT method should be developed because the regular CT may aggravate the disease. METHOD: Sixty cases were randomly divided into the study group (n = 30) and control group (n = 30). The lung window was reconstructed by Karl 3D iterative technique in the study group. The image quality was subjectively evaluated by two senior chest group diagnostic physicians using a 5-point double-blind method. The value of CT measurement and its standard deviation (SD) was used as an objective evaluation criteria. The volume of CT dose index (CTDI(vol)), dose length product (DLP) and effective dose (ED) from the two groups were compared and analyzed statistically. RESULT: There was no significant difference in the occurrence rates of ground glass opacities, consolidation, crazy-paving pattern, fiber cable shadow and axial interstitial thickening between the study group and control group (p > 0.05). In addition, no significant difference was found for the subjective score of overall image quality and image noise level (SD) between the two groups (p > 0.05). However, significant differences was found in CTDI(vol), DLP, and ED between the study group and the control group (p < 0.05). The effective dose of the study group was reduced by 76% compared to the control group. CONCLUSION: CareDose 4D low-dose scanning combined with Karl 3D iterative reconstruction technology can not only greatly reduce the radiation dose, but also provide images that meet the diagnostic criteria of COVID-19, which can be used as a routine method for the follow-up of COVID-19 patients. BioMed Central 2020-05-24 /pmc/articles/PMC7245769/ /pubmed/32448136 http://dx.doi.org/10.1186/s12880-020-00456-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Li, Jiawei
Wang, Xiao
Huang, Xiaolu
Chen, Fangxing
Zhang, Xuesong
Liu, Ying
Luo, Guangzuo
Xu, Xunhua
Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title_full Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title_fullStr Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title_full_unstemmed Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title_short Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19
title_sort application of caredose 4d combined with karl 3d technology in the low dose computed tomography for the follow-up of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245769/
https://www.ncbi.nlm.nih.gov/pubmed/32448136
http://dx.doi.org/10.1186/s12880-020-00456-5
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