Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disease characterized by heterotopic ossification (HO) in soft tissues and caused by a mutation of the ACVR1A/ALK2 gene. Activin-A is a key molecule for initiating the process of HO via the activation of mTOR, while...

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Detalles Bibliográficos
Autores principales: Maekawa, Hirotsugu, Kawai, Shunsuke, Nishio, Megumi, Nagata, Sanae, Jin, Yonghui, Yoshitomi, Hiroyuki, Matsuda, Shuichi, Toguchida, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245788/
https://www.ncbi.nlm.nih.gov/pubmed/32448372
http://dx.doi.org/10.1186/s13023-020-01406-8

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