Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells

RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a critical element in proliferation of stem and cancer stem cells, which acts through Wnt and Not...

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Autores principales: Forouzanfar, Mahboobeh, Lachinani, Liana, Dormiani, Kianoush, Nasr-Esfahani, Mohammad Hossein, Gure, Ali Osmay, Ghaedi, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245930/
https://www.ncbi.nlm.nih.gov/pubmed/32448364
http://dx.doi.org/10.1186/s13287-020-01703-w
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author Forouzanfar, Mahboobeh
Lachinani, Liana
Dormiani, Kianoush
Nasr-Esfahani, Mohammad Hossein
Gure, Ali Osmay
Ghaedi, Kamran
author_facet Forouzanfar, Mahboobeh
Lachinani, Liana
Dormiani, Kianoush
Nasr-Esfahani, Mohammad Hossein
Gure, Ali Osmay
Ghaedi, Kamran
author_sort Forouzanfar, Mahboobeh
collection PubMed
description RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a critical element in proliferation of stem and cancer stem cells, which acts through Wnt and Notch signaling pathways. Moreover, MSI1 modulates malignancy and chemoresistance of lung cancer cells via activating the Akt signaling. Due to the main role of MSI1 in metastasis and cancer development, MSI1 would be an appropriate candidate for cancer therapy. Downregulation of MSI1 inhibits proliferation of cancer stem cells and reduces the growth of solid tumors in several cancers. On the other hand, MSI1 expression is regulated by microRNAs in such a way that several different tumor suppressor miRNAs negatively regulate oncogenic MSI1 and inhibit migration and tumor metastasis. The aim of this review is summarizing the role of MSI1 in stem cell proliferation and cancer promotion.
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spelling pubmed-72459302020-06-01 Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells Forouzanfar, Mahboobeh Lachinani, Liana Dormiani, Kianoush Nasr-Esfahani, Mohammad Hossein Gure, Ali Osmay Ghaedi, Kamran Stem Cell Res Ther Review RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a critical element in proliferation of stem and cancer stem cells, which acts through Wnt and Notch signaling pathways. Moreover, MSI1 modulates malignancy and chemoresistance of lung cancer cells via activating the Akt signaling. Due to the main role of MSI1 in metastasis and cancer development, MSI1 would be an appropriate candidate for cancer therapy. Downregulation of MSI1 inhibits proliferation of cancer stem cells and reduces the growth of solid tumors in several cancers. On the other hand, MSI1 expression is regulated by microRNAs in such a way that several different tumor suppressor miRNAs negatively regulate oncogenic MSI1 and inhibit migration and tumor metastasis. The aim of this review is summarizing the role of MSI1 in stem cell proliferation and cancer promotion. BioMed Central 2020-05-24 /pmc/articles/PMC7245930/ /pubmed/32448364 http://dx.doi.org/10.1186/s13287-020-01703-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Forouzanfar, Mahboobeh
Lachinani, Liana
Dormiani, Kianoush
Nasr-Esfahani, Mohammad Hossein
Gure, Ali Osmay
Ghaedi, Kamran
Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title_full Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title_fullStr Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title_full_unstemmed Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title_short Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
title_sort intracellular functions of rna-binding protein, musashi1, in stem and cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245930/
https://www.ncbi.nlm.nih.gov/pubmed/32448364
http://dx.doi.org/10.1186/s13287-020-01703-w
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