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Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks

Wortmannin, a fungal metabolite, is a specific inhibitor of the phosphatidylinositol 3-kinase (PI3K) family, which includes double-stranded DNA dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated kinase (ATM). We investigated the effects of wortmannin on DNA damage in DNA-PK-deficien...

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Detalles Bibliográficos
Autores principales:	Ihara, Makoto, Shichijo, Kazuko, Takeshita, Satoshi, Kudo, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Regular Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246056/ https://www.ncbi.nlm.nih.gov/pubmed/32052028 http://dx.doi.org/10.1093/jrr/rrz102

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