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The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases

AIM: In the present study, we purposed to determine serum chitinase 3‐like 1 (CHI3L1) expression characteristics in chronic liver diseases monoinfected with hepatitis B virus and analyze its diagnostic value in liver fibrosis. METHODS: A total of 467 chronic hepatitis B (CHB) patients, 312 liver cir...

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Autores principales: Jiang, Zhenluo, Wang, Shuwei, Jin, Jiancheng, Ying, Sheng, Chen, Zhigang, Zhu, Dedong, Xiao, Bingxiu, Hu, Yaoren, Qian, Yunsong, Cai, Ting, Fu, Liyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246367/
https://www.ncbi.nlm.nih.gov/pubmed/31916309
http://dx.doi.org/10.1002/jcla.23200
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author Jiang, Zhenluo
Wang, Shuwei
Jin, Jiancheng
Ying, Sheng
Chen, Zhigang
Zhu, Dedong
Xiao, Bingxiu
Hu, Yaoren
Qian, Yunsong
Cai, Ting
Fu, Liyun
author_facet Jiang, Zhenluo
Wang, Shuwei
Jin, Jiancheng
Ying, Sheng
Chen, Zhigang
Zhu, Dedong
Xiao, Bingxiu
Hu, Yaoren
Qian, Yunsong
Cai, Ting
Fu, Liyun
author_sort Jiang, Zhenluo
collection PubMed
description AIM: In the present study, we purposed to determine serum chitinase 3‐like 1 (CHI3L1) expression characteristics in chronic liver diseases monoinfected with hepatitis B virus and analyze its diagnostic value in liver fibrosis. METHODS: A total of 467 chronic hepatitis B (CHB) patients, 312 liver cirrhosis (LC) patients, and 104 hepatocellular carcinoma (HCC) patients at our institution were enrolled, and clinical indicators were analyzed. RESULTS: Our data have shown that the expression level of serum CHI3L1 was steadily increased from CHB to LC to HCC (P < .001). Serum CHI3L1 expression levels were positively associated with liver stiffness measurement (LSM), fibrosis‐4 (FIB‐4) index, aspartate aminotransferase‐to‐platelet ratio index (APRI), and HCC stage. The receiver operating characteristic (ROC) curve proved that serum CHI3L1 was superior to other noninvasive methods (LSM, FIB‐4, and APRI) with an area under the ROC curve (AUC) of 0.97 in diagnosing significant fibrosis. CONCLUSIONS: Serum CHI3L1 harbors significant clinical value in chronic liver diseases infected with hepatitis B virus, especially in the diagnosis of fibrosis.
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spelling pubmed-72463672020-06-01 The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases Jiang, Zhenluo Wang, Shuwei Jin, Jiancheng Ying, Sheng Chen, Zhigang Zhu, Dedong Xiao, Bingxiu Hu, Yaoren Qian, Yunsong Cai, Ting Fu, Liyun J Clin Lab Anal Research Articles AIM: In the present study, we purposed to determine serum chitinase 3‐like 1 (CHI3L1) expression characteristics in chronic liver diseases monoinfected with hepatitis B virus and analyze its diagnostic value in liver fibrosis. METHODS: A total of 467 chronic hepatitis B (CHB) patients, 312 liver cirrhosis (LC) patients, and 104 hepatocellular carcinoma (HCC) patients at our institution were enrolled, and clinical indicators were analyzed. RESULTS: Our data have shown that the expression level of serum CHI3L1 was steadily increased from CHB to LC to HCC (P < .001). Serum CHI3L1 expression levels were positively associated with liver stiffness measurement (LSM), fibrosis‐4 (FIB‐4) index, aspartate aminotransferase‐to‐platelet ratio index (APRI), and HCC stage. The receiver operating characteristic (ROC) curve proved that serum CHI3L1 was superior to other noninvasive methods (LSM, FIB‐4, and APRI) with an area under the ROC curve (AUC) of 0.97 in diagnosing significant fibrosis. CONCLUSIONS: Serum CHI3L1 harbors significant clinical value in chronic liver diseases infected with hepatitis B virus, especially in the diagnosis of fibrosis. John Wiley and Sons Inc. 2020-01-08 /pmc/articles/PMC7246367/ /pubmed/31916309 http://dx.doi.org/10.1002/jcla.23200 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Jiang, Zhenluo
Wang, Shuwei
Jin, Jiancheng
Ying, Sheng
Chen, Zhigang
Zhu, Dedong
Xiao, Bingxiu
Hu, Yaoren
Qian, Yunsong
Cai, Ting
Fu, Liyun
The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title_full The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title_fullStr The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title_full_unstemmed The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title_short The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases
title_sort clinical significance of serum chitinase 3‐like 1 in hepatitis b–related chronic liver diseases
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246367/
https://www.ncbi.nlm.nih.gov/pubmed/31916309
http://dx.doi.org/10.1002/jcla.23200
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