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Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China
BACKGROUND: To calculate the reference intervals for thyroid‐stimulating hormone (TSH) and thyroid hormones using the Access TSH 3rd IS method and evaluate the differences between age and genders in Chinese populations. METHODS: This study collected 349 serum samples of healthy subjects were from Sh...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246370/ https://www.ncbi.nlm.nih.gov/pubmed/31912542 http://dx.doi.org/10.1002/jcla.23197 |
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author | Li, Zhen‐Zhen Yu, Ben‐Zhang Wang, Ji‐Liang Yang, Qin Ming, Jia Tang, Yu‐Rong |
author_facet | Li, Zhen‐Zhen Yu, Ben‐Zhang Wang, Ji‐Liang Yang, Qin Ming, Jia Tang, Yu‐Rong |
author_sort | Li, Zhen‐Zhen |
collection | PubMed |
description | BACKGROUND: To calculate the reference intervals for thyroid‐stimulating hormone (TSH) and thyroid hormones using the Access TSH 3rd IS method and evaluate the differences between age and genders in Chinese populations. METHODS: This study collected 349 serum samples of healthy subjects were from Shengli Oilfield Central Hospital in China. Subjects who tested positive for thyroid peroxidase antibody or thyroglobulin antibody were excluded. Accordingly, 313 subjects were included for establishing reference intervals for the thyroid hormones. The serum concentrations of TSH, total and free thyroxine (TT4 and FT4), and total and free triiodothyronine (TT3 and FT3) were measured using the Access TSH 3rd IS method. The 2.5th and 97.5th percentiles or mean with standard deviation were calculated as the reference interval as appropriate. RESULTS: The reference intervals for TSH, FT4, FT3, TT4, and TT3 calculated in present study were 0.61‐4.16 mIU/L, 0.67‐1.11 ng/dL, 2.63‐4.33 pg/mL, 5.56‐11.33 μg/dL, and 0.72‐1.32 ng/mL, respectively. The FT3, TT4, and TT3 levels in males were significantly higher than in females (P < .05), while TSH levels in males were significantly lower than in females (P < .05). The levels of FT3 in subjects with the age of less than 30 years were significantly higher than other groups (P < .05). CONCLUSION: The present study provided a valid basis for the reference intervals for TSH, FT4, FT3, TT4, and TT3 in Chinese populations. In addition, this present study indicated that age and gender should be considered in diagnostic evaluation of thyroid diseases. |
format | Online Article Text |
id | pubmed-7246370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72463702020-06-01 Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China Li, Zhen‐Zhen Yu, Ben‐Zhang Wang, Ji‐Liang Yang, Qin Ming, Jia Tang, Yu‐Rong J Clin Lab Anal Research Articles BACKGROUND: To calculate the reference intervals for thyroid‐stimulating hormone (TSH) and thyroid hormones using the Access TSH 3rd IS method and evaluate the differences between age and genders in Chinese populations. METHODS: This study collected 349 serum samples of healthy subjects were from Shengli Oilfield Central Hospital in China. Subjects who tested positive for thyroid peroxidase antibody or thyroglobulin antibody were excluded. Accordingly, 313 subjects were included for establishing reference intervals for the thyroid hormones. The serum concentrations of TSH, total and free thyroxine (TT4 and FT4), and total and free triiodothyronine (TT3 and FT3) were measured using the Access TSH 3rd IS method. The 2.5th and 97.5th percentiles or mean with standard deviation were calculated as the reference interval as appropriate. RESULTS: The reference intervals for TSH, FT4, FT3, TT4, and TT3 calculated in present study were 0.61‐4.16 mIU/L, 0.67‐1.11 ng/dL, 2.63‐4.33 pg/mL, 5.56‐11.33 μg/dL, and 0.72‐1.32 ng/mL, respectively. The FT3, TT4, and TT3 levels in males were significantly higher than in females (P < .05), while TSH levels in males were significantly lower than in females (P < .05). The levels of FT3 in subjects with the age of less than 30 years were significantly higher than other groups (P < .05). CONCLUSION: The present study provided a valid basis for the reference intervals for TSH, FT4, FT3, TT4, and TT3 in Chinese populations. In addition, this present study indicated that age and gender should be considered in diagnostic evaluation of thyroid diseases. John Wiley and Sons Inc. 2020-01-08 /pmc/articles/PMC7246370/ /pubmed/31912542 http://dx.doi.org/10.1002/jcla.23197 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Li, Zhen‐Zhen Yu, Ben‐Zhang Wang, Ji‐Liang Yang, Qin Ming, Jia Tang, Yu‐Rong Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title | Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title_full | Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title_fullStr | Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title_full_unstemmed | Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title_short | Reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China |
title_sort | reference intervals for thyroid‐stimulating hormone and thyroid hormones using the access tsh 3rd is method in china |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246370/ https://www.ncbi.nlm.nih.gov/pubmed/31912542 http://dx.doi.org/10.1002/jcla.23197 |
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