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tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly's health. Therefore, these nutritional problems have become a concern to human health...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246405/ https://www.ncbi.nlm.nih.gov/pubmed/32509140 http://dx.doi.org/10.1155/2020/3123268 |
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author | Posadas-Rodríguez, Pedro Posadas-Rodríguez, Natalia Esmeralda González-Puertos, Viridiana Yazmín Toledo-Pérez, Rafael Ventura-Gallegos, José Luis Zentella, Alejandro Gómez-Quiroz, Luis Enrique Königsberg, Mina Luna-López, Armando |
author_facet | Posadas-Rodríguez, Pedro Posadas-Rodríguez, Natalia Esmeralda González-Puertos, Viridiana Yazmín Toledo-Pérez, Rafael Ventura-Gallegos, José Luis Zentella, Alejandro Gómez-Quiroz, Luis Enrique Königsberg, Mina Luna-López, Armando |
author_sort | Posadas-Rodríguez, Pedro |
collection | PubMed |
description | Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly's health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB. |
format | Online Article Text |
id | pubmed-7246405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72464052020-06-06 tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate Posadas-Rodríguez, Pedro Posadas-Rodríguez, Natalia Esmeralda González-Puertos, Viridiana Yazmín Toledo-Pérez, Rafael Ventura-Gallegos, José Luis Zentella, Alejandro Gómez-Quiroz, Luis Enrique Königsberg, Mina Luna-López, Armando Oxid Med Cell Longev Research Article Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly's health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB. Hindawi 2020-05-16 /pmc/articles/PMC7246405/ /pubmed/32509140 http://dx.doi.org/10.1155/2020/3123268 Text en Copyright © 2020 Pedro Posadas-Rodríguez et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Posadas-Rodríguez, Pedro Posadas-Rodríguez, Natalia Esmeralda González-Puertos, Viridiana Yazmín Toledo-Pérez, Rafael Ventura-Gallegos, José Luis Zentella, Alejandro Gómez-Quiroz, Luis Enrique Königsberg, Mina Luna-López, Armando tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title | tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_full | tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_fullStr | tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_full_unstemmed | tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_short | tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_sort | tbhq induces a hormetic response that protects l6 myoblasts against the toxic effect of palmitate |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246405/ https://www.ncbi.nlm.nih.gov/pubmed/32509140 http://dx.doi.org/10.1155/2020/3123268 |
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