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The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is sti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246426/ https://www.ncbi.nlm.nih.gov/pubmed/32365893 http://dx.doi.org/10.3390/ijms21093172 |
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author | Chang, Ting-Ting Chen, Jaw-Wen |
author_facet | Chang, Ting-Ting Chen, Jaw-Wen |
author_sort | Chang, Ting-Ting |
collection | PubMed |
description | Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN. |
format | Online Article Text |
id | pubmed-7246426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72464262020-06-11 The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy Chang, Ting-Ting Chen, Jaw-Wen Int J Mol Sci Review Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN. MDPI 2020-04-30 /pmc/articles/PMC7246426/ /pubmed/32365893 http://dx.doi.org/10.3390/ijms21093172 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chang, Ting-Ting Chen, Jaw-Wen The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title | The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title_full | The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title_fullStr | The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title_full_unstemmed | The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title_short | The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy |
title_sort | role of chemokines and chemokine receptors in diabetic nephropathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246426/ https://www.ncbi.nlm.nih.gov/pubmed/32365893 http://dx.doi.org/10.3390/ijms21093172 |
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