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The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy

Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is sti...

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Autores principales: Chang, Ting-Ting, Chen, Jaw-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246426/
https://www.ncbi.nlm.nih.gov/pubmed/32365893
http://dx.doi.org/10.3390/ijms21093172
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author Chang, Ting-Ting
Chen, Jaw-Wen
author_facet Chang, Ting-Ting
Chen, Jaw-Wen
author_sort Chang, Ting-Ting
collection PubMed
description Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN.
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spelling pubmed-72464262020-06-11 The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy Chang, Ting-Ting Chen, Jaw-Wen Int J Mol Sci Review Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN. MDPI 2020-04-30 /pmc/articles/PMC7246426/ /pubmed/32365893 http://dx.doi.org/10.3390/ijms21093172 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Ting-Ting
Chen, Jaw-Wen
The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title_full The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title_fullStr The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title_full_unstemmed The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title_short The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy
title_sort role of chemokines and chemokine receptors in diabetic nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246426/
https://www.ncbi.nlm.nih.gov/pubmed/32365893
http://dx.doi.org/10.3390/ijms21093172
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