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Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study

The paucity of epidemiological data regarding diabetes complications in Brazil motivated us to evaluate the prevalence rates of distal symmetric polyneuropathy (DSP) and of cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes (T2D) followed in a primary care unit. A total of...

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Autores principales: Reis de Matos, Mozania, Santos-Bezerra, Daniele Pereira, Dias Cavalcante, Cristiane das Graças, Xavier de Carvalho, Jacira, Leite, Juliana, Neves, Jose Antonio Januario, Admoni, Sharon Nina, Passarelli, Marisa, Parisi, Maria Candida, Correa-Giannella, Maria Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246466/
https://www.ncbi.nlm.nih.gov/pubmed/32384735
http://dx.doi.org/10.3390/ijerph17093232
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author Reis de Matos, Mozania
Santos-Bezerra, Daniele Pereira
Dias Cavalcante, Cristiane das Graças
Xavier de Carvalho, Jacira
Leite, Juliana
Neves, Jose Antonio Januario
Admoni, Sharon Nina
Passarelli, Marisa
Parisi, Maria Candida
Correa-Giannella, Maria Lucia
author_facet Reis de Matos, Mozania
Santos-Bezerra, Daniele Pereira
Dias Cavalcante, Cristiane das Graças
Xavier de Carvalho, Jacira
Leite, Juliana
Neves, Jose Antonio Januario
Admoni, Sharon Nina
Passarelli, Marisa
Parisi, Maria Candida
Correa-Giannella, Maria Lucia
author_sort Reis de Matos, Mozania
collection PubMed
description The paucity of epidemiological data regarding diabetes complications in Brazil motivated us to evaluate the prevalence rates of distal symmetric polyneuropathy (DSP) and of cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes (T2D) followed in a primary care unit. A total of 551 individuals (59.3% women, 65 years old; diabetes duration of 10 years; HbA1c of 7.2%, medians) were included in this cross-sectional study. DSP was diagnosed by sum of the Neuropathy Symptoms Score (NSS) and Modified Neuropathy Disability Score (NDS) and by the Semmes–Weinstein monofilament. CAN was diagnosed by cardiovascular autonomic reflex tests combined with spectral analysis of heart rate variability. The prevalence rates of DSP were 6.3% and 14.3%, as evaluated by the sum of NSS and NDS and by the Semmes–Weinstein monofilament, respectively. Those with DSP diagnosed by monofilament presented longer diabetes duration, worse glycemic control and a higher stature. The prevalence rates of incipient and definitive CAN were 12.5% and 10%, respectively. Individuals with definitive CAN presented a higher frequency of hypercholesterolemia and of arterial hypertension. The higher prevalence rate of DSP with the use of the monofilament suggests that it may be a more appropriate tool to diagnose DSP in the primary care setting in Brazil.
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spelling pubmed-72464662020-06-11 Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study Reis de Matos, Mozania Santos-Bezerra, Daniele Pereira Dias Cavalcante, Cristiane das Graças Xavier de Carvalho, Jacira Leite, Juliana Neves, Jose Antonio Januario Admoni, Sharon Nina Passarelli, Marisa Parisi, Maria Candida Correa-Giannella, Maria Lucia Int J Environ Res Public Health Article The paucity of epidemiological data regarding diabetes complications in Brazil motivated us to evaluate the prevalence rates of distal symmetric polyneuropathy (DSP) and of cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes (T2D) followed in a primary care unit. A total of 551 individuals (59.3% women, 65 years old; diabetes duration of 10 years; HbA1c of 7.2%, medians) were included in this cross-sectional study. DSP was diagnosed by sum of the Neuropathy Symptoms Score (NSS) and Modified Neuropathy Disability Score (NDS) and by the Semmes–Weinstein monofilament. CAN was diagnosed by cardiovascular autonomic reflex tests combined with spectral analysis of heart rate variability. The prevalence rates of DSP were 6.3% and 14.3%, as evaluated by the sum of NSS and NDS and by the Semmes–Weinstein monofilament, respectively. Those with DSP diagnosed by monofilament presented longer diabetes duration, worse glycemic control and a higher stature. The prevalence rates of incipient and definitive CAN were 12.5% and 10%, respectively. Individuals with definitive CAN presented a higher frequency of hypercholesterolemia and of arterial hypertension. The higher prevalence rate of DSP with the use of the monofilament suggests that it may be a more appropriate tool to diagnose DSP in the primary care setting in Brazil. MDPI 2020-05-06 2020-05 /pmc/articles/PMC7246466/ /pubmed/32384735 http://dx.doi.org/10.3390/ijerph17093232 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reis de Matos, Mozania
Santos-Bezerra, Daniele Pereira
Dias Cavalcante, Cristiane das Graças
Xavier de Carvalho, Jacira
Leite, Juliana
Neves, Jose Antonio Januario
Admoni, Sharon Nina
Passarelli, Marisa
Parisi, Maria Candida
Correa-Giannella, Maria Lucia
Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title_full Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title_fullStr Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title_full_unstemmed Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title_short Distal Symmetric and Cardiovascular Autonomic Neuropathies in Brazilian Individuals with Type 2 Diabetes Followed in a Primary Health Care Unit: A Cross-Sectional Study
title_sort distal symmetric and cardiovascular autonomic neuropathies in brazilian individuals with type 2 diabetes followed in a primary health care unit: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246466/
https://www.ncbi.nlm.nih.gov/pubmed/32384735
http://dx.doi.org/10.3390/ijerph17093232
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