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Airway Microbiota as a Modulator of Lung Cancer
Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic conditio...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246469/ https://www.ncbi.nlm.nih.gov/pubmed/32357415 http://dx.doi.org/10.3390/ijms21093044 |
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author | Goto, Taichiro |
author_facet | Goto, Taichiro |
author_sort | Goto, Taichiro |
collection | PubMed |
description | Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic condition is associated with lung carcinogenesis, the underlying mechanisms remain unclear. Microorganisms possibly trigger tumor initiation and progression, presumably via the production of bacterial toxins and other pro-inflammatory factors. The purpose of this review is to discuss the basic role of the airway microbiome in carcinogenesis and the underlying molecular mechanisms, with the aim of developing anticancer strategies involving the airway microbiota. In addition, the mechanisms via which the microbiome acts as a modulator of immunotherapies in lung cancer are summarized. |
format | Online Article Text |
id | pubmed-7246469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72464692020-06-11 Airway Microbiota as a Modulator of Lung Cancer Goto, Taichiro Int J Mol Sci Review Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic condition is associated with lung carcinogenesis, the underlying mechanisms remain unclear. Microorganisms possibly trigger tumor initiation and progression, presumably via the production of bacterial toxins and other pro-inflammatory factors. The purpose of this review is to discuss the basic role of the airway microbiome in carcinogenesis and the underlying molecular mechanisms, with the aim of developing anticancer strategies involving the airway microbiota. In addition, the mechanisms via which the microbiome acts as a modulator of immunotherapies in lung cancer are summarized. MDPI 2020-04-26 /pmc/articles/PMC7246469/ /pubmed/32357415 http://dx.doi.org/10.3390/ijms21093044 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Goto, Taichiro Airway Microbiota as a Modulator of Lung Cancer |
title | Airway Microbiota as a Modulator of Lung Cancer |
title_full | Airway Microbiota as a Modulator of Lung Cancer |
title_fullStr | Airway Microbiota as a Modulator of Lung Cancer |
title_full_unstemmed | Airway Microbiota as a Modulator of Lung Cancer |
title_short | Airway Microbiota as a Modulator of Lung Cancer |
title_sort | airway microbiota as a modulator of lung cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246469/ https://www.ncbi.nlm.nih.gov/pubmed/32357415 http://dx.doi.org/10.3390/ijms21093044 |
work_keys_str_mv | AT gototaichiro airwaymicrobiotaasamodulatoroflungcancer |