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Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis

Background—It is recognized that inflammation is an underlying cause of dry eye disease (DED), with cytokine release involved. We systematically reviewed literature with meta-analyses to quantitatively summarize the levels of tear cytokines in DED. Methods—The PubMed, Embase, Web of Science, Ovid, C...

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Autores principales: Roda, Matilde, Corazza, Ivan, Bacchi Reggiani, Maria Letizia, Pellegrini, Marco, Taroni, Leonardo, Giannaccare, Giuseppe, Versura, Piera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246678/
https://www.ncbi.nlm.nih.gov/pubmed/32354090
http://dx.doi.org/10.3390/ijms21093111
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author Roda, Matilde
Corazza, Ivan
Bacchi Reggiani, Maria Letizia
Pellegrini, Marco
Taroni, Leonardo
Giannaccare, Giuseppe
Versura, Piera
author_facet Roda, Matilde
Corazza, Ivan
Bacchi Reggiani, Maria Letizia
Pellegrini, Marco
Taroni, Leonardo
Giannaccare, Giuseppe
Versura, Piera
author_sort Roda, Matilde
collection PubMed
description Background—It is recognized that inflammation is an underlying cause of dry eye disease (DED), with cytokine release involved. We systematically reviewed literature with meta-analyses to quantitatively summarize the levels of tear cytokines in DED. Methods—The PubMed, Embase, Web of Science, Ovid, Cochrane, and Scopus databases were reviewed until September 2019, and original articles investigating tear cytokines in DED patients were included. Differences of cytokines levels of DED patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed by applying Newcastle-Ottawa-Scale and the GRADE quality score. Methods of analytical procedures were included as covariate. Results—Thirteen articles investigating 342 DED patients and 205 healthy controls were included in the meta-analysis. The overall methodological quality of these studies was moderate. Systematic review of the selected articles revealed that DED patients had higher tear levels of interleukin (IL)-1β, IL-6, chemokine IL-8, IL-10, interferon-γ, IFN-γ, and tumor necrosis factor-α, TNF-α as compared to controls. Evidence was less strong for IL-2 and IL-17A. Conclusions—Data show that levels of tear cytokines in DED and control display a great variability, and further studies of higher quality enrolling a higher number of subjects are needed, to define a cut-off value.
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spelling pubmed-72466782020-06-10 Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis Roda, Matilde Corazza, Ivan Bacchi Reggiani, Maria Letizia Pellegrini, Marco Taroni, Leonardo Giannaccare, Giuseppe Versura, Piera Int J Mol Sci Review Background—It is recognized that inflammation is an underlying cause of dry eye disease (DED), with cytokine release involved. We systematically reviewed literature with meta-analyses to quantitatively summarize the levels of tear cytokines in DED. Methods—The PubMed, Embase, Web of Science, Ovid, Cochrane, and Scopus databases were reviewed until September 2019, and original articles investigating tear cytokines in DED patients were included. Differences of cytokines levels of DED patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed by applying Newcastle-Ottawa-Scale and the GRADE quality score. Methods of analytical procedures were included as covariate. Results—Thirteen articles investigating 342 DED patients and 205 healthy controls were included in the meta-analysis. The overall methodological quality of these studies was moderate. Systematic review of the selected articles revealed that DED patients had higher tear levels of interleukin (IL)-1β, IL-6, chemokine IL-8, IL-10, interferon-γ, IFN-γ, and tumor necrosis factor-α, TNF-α as compared to controls. Evidence was less strong for IL-2 and IL-17A. Conclusions—Data show that levels of tear cytokines in DED and control display a great variability, and further studies of higher quality enrolling a higher number of subjects are needed, to define a cut-off value. MDPI 2020-04-28 /pmc/articles/PMC7246678/ /pubmed/32354090 http://dx.doi.org/10.3390/ijms21093111 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roda, Matilde
Corazza, Ivan
Bacchi Reggiani, Maria Letizia
Pellegrini, Marco
Taroni, Leonardo
Giannaccare, Giuseppe
Versura, Piera
Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title_full Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title_fullStr Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title_full_unstemmed Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title_short Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis
title_sort dry eye disease and tear cytokine levels—a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246678/
https://www.ncbi.nlm.nih.gov/pubmed/32354090
http://dx.doi.org/10.3390/ijms21093111
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