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Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer
Novel anti-cancer treatments have improved the survival rates of female young patients, reopening pregnancy issues for female cancer survivors affected by the tumor treatment-related infertility. This condition occurs in approximately one third of women of fertile age and is mainly dependent on gona...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246700/ https://www.ncbi.nlm.nih.gov/pubmed/32375324 http://dx.doi.org/10.3390/ijms21093245 |
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author | Silvestris, Erica De Palma, Giuseppe Canosa, Stefano Palini, Simone Dellino, Miriam Revelli, Alberto Paradiso, Angelo Virgilio |
author_facet | Silvestris, Erica De Palma, Giuseppe Canosa, Stefano Palini, Simone Dellino, Miriam Revelli, Alberto Paradiso, Angelo Virgilio |
author_sort | Silvestris, Erica |
collection | PubMed |
description | Novel anti-cancer treatments have improved the survival rates of female young patients, reopening pregnancy issues for female cancer survivors affected by the tumor treatment-related infertility. This condition occurs in approximately one third of women of fertile age and is mainly dependent on gonadotoxic protocols, including radiation treatments. Besides routine procedures such as the hormonal induction of follicular growth and subsequent cryopreservation of oocytes or embryos, the ovarian protection by gonadotropin-releasing hormone (GnRH) agonists during chemotherapy as well as even gonadal shielding during radiotherapy, other innovative techniques are available today and need to be optimized to support their introduction into the clinical practice. These novel methods are hormone stimulation-free and include the ovarian cortex cryopreservation before anti-cancer treatments and its subsequent autologous reimplantation and a regenerative medicine approach using oocytes derived in vitro from ovarian stem cells (OSCs). For both procedures, the major benefit is related to the prompt recruitment and processing of the ovarian cortex fragments before gonadotoxic treatments. However, while the functional competence of oocytes within the cryopreserved cortex is not assessable, the in vitro maturation of OSCs to oocytes, allows to select the most competent eggs to be cryopreserved for fertility restoration. |
format | Online Article Text |
id | pubmed-7246700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72467002020-06-10 Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer Silvestris, Erica De Palma, Giuseppe Canosa, Stefano Palini, Simone Dellino, Miriam Revelli, Alberto Paradiso, Angelo Virgilio Int J Mol Sci Review Novel anti-cancer treatments have improved the survival rates of female young patients, reopening pregnancy issues for female cancer survivors affected by the tumor treatment-related infertility. This condition occurs in approximately one third of women of fertile age and is mainly dependent on gonadotoxic protocols, including radiation treatments. Besides routine procedures such as the hormonal induction of follicular growth and subsequent cryopreservation of oocytes or embryos, the ovarian protection by gonadotropin-releasing hormone (GnRH) agonists during chemotherapy as well as even gonadal shielding during radiotherapy, other innovative techniques are available today and need to be optimized to support their introduction into the clinical practice. These novel methods are hormone stimulation-free and include the ovarian cortex cryopreservation before anti-cancer treatments and its subsequent autologous reimplantation and a regenerative medicine approach using oocytes derived in vitro from ovarian stem cells (OSCs). For both procedures, the major benefit is related to the prompt recruitment and processing of the ovarian cortex fragments before gonadotoxic treatments. However, while the functional competence of oocytes within the cryopreserved cortex is not assessable, the in vitro maturation of OSCs to oocytes, allows to select the most competent eggs to be cryopreserved for fertility restoration. MDPI 2020-05-04 /pmc/articles/PMC7246700/ /pubmed/32375324 http://dx.doi.org/10.3390/ijms21093245 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silvestris, Erica De Palma, Giuseppe Canosa, Stefano Palini, Simone Dellino, Miriam Revelli, Alberto Paradiso, Angelo Virgilio Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title | Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title_full | Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title_fullStr | Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title_full_unstemmed | Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title_short | Human Ovarian Cortex biobanking: A Fascinating Resource for Fertility Preservation in Cancer |
title_sort | human ovarian cortex biobanking: a fascinating resource for fertility preservation in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246700/ https://www.ncbi.nlm.nih.gov/pubmed/32375324 http://dx.doi.org/10.3390/ijms21093245 |
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