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MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension
In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246754/ https://www.ncbi.nlm.nih.gov/pubmed/32375361 http://dx.doi.org/10.3390/ijms21093253 |
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author | Carregal-Romero, Susana Fadón, Lucía Berra, Edurne Ruíz-Cabello, Jesús |
author_facet | Carregal-Romero, Susana Fadón, Lucía Berra, Edurne Ruíz-Cabello, Jesús |
author_sort | Carregal-Romero, Susana |
collection | PubMed |
description | In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension. |
format | Online Article Text |
id | pubmed-7246754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72467542020-06-10 MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension Carregal-Romero, Susana Fadón, Lucía Berra, Edurne Ruíz-Cabello, Jesús Int J Mol Sci Review In this review, the potential future role of microRNA-based therapies and their specific application in lung diseases is reported with special attention to pulmonary hypertension. Current limitations of these therapies will be pointed out in order to address the challenges that they need to face to reach clinical applications. In this context, the encapsulation of microRNA-based therapies in nanovectors has shown improvements as compared to chemically modified microRNAs toward enhanced stability, efficacy, reduced side effects, and local administration. All these concepts will contextualize in this review the recent achievements and expectations reported for the treatment of pulmonary hypertension. MDPI 2020-05-04 /pmc/articles/PMC7246754/ /pubmed/32375361 http://dx.doi.org/10.3390/ijms21093253 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carregal-Romero, Susana Fadón, Lucía Berra, Edurne Ruíz-Cabello, Jesús MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title_full | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title_fullStr | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title_full_unstemmed | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title_short | MicroRNA Nanotherapeutics for Lung Targeting. Insights into Pulmonary Hypertension |
title_sort | microrna nanotherapeutics for lung targeting. insights into pulmonary hypertension |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246754/ https://www.ncbi.nlm.nih.gov/pubmed/32375361 http://dx.doi.org/10.3390/ijms21093253 |
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