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Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities

A wide variety of uniquely localized actin-binding proteins (ABPs) are involved in various cellular activities, such as cytokinesis, migration, adhesion, morphogenesis, and intracellular transport. In a micrometer-scale space such as the inside of cells, protein molecules diffuse throughout the cell...

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Autores principales: Tokuraku, Kiyotaka, Kuragano, Masahiro, Uyeda, Taro Q. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246755/
https://www.ncbi.nlm.nih.gov/pubmed/32370032
http://dx.doi.org/10.3390/ijms21093209
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author Tokuraku, Kiyotaka
Kuragano, Masahiro
Uyeda, Taro Q. P.
author_facet Tokuraku, Kiyotaka
Kuragano, Masahiro
Uyeda, Taro Q. P.
author_sort Tokuraku, Kiyotaka
collection PubMed
description A wide variety of uniquely localized actin-binding proteins (ABPs) are involved in various cellular activities, such as cytokinesis, migration, adhesion, morphogenesis, and intracellular transport. In a micrometer-scale space such as the inside of cells, protein molecules diffuse throughout the cell interior within seconds. In this condition, how can ABPs selectively bind to particular actin filaments when there is an abundance of actin filaments in the cytoplasm? In recent years, several ABPs have been reported to induce cooperative conformational changes to actin filaments allowing structural changes to propagate along the filament cables uni- or bidirectionally, thereby regulating the subsequent binding of ABPs. Such propagation of ABP-induced cooperative conformational changes in actin filaments may be advantageous for the elaborate regulation of cellular activities driven by actin-based machineries in the intracellular space, which is dominated by diffusion. In this review, we focus on long-range allosteric regulation driven by cooperative conformational changes of actin filaments that are evoked by binding of ABPs, and discuss roles of allostery of actin filaments in narrow intracellular spaces.
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spelling pubmed-72467552020-06-10 Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities Tokuraku, Kiyotaka Kuragano, Masahiro Uyeda, Taro Q. P. Int J Mol Sci Review A wide variety of uniquely localized actin-binding proteins (ABPs) are involved in various cellular activities, such as cytokinesis, migration, adhesion, morphogenesis, and intracellular transport. In a micrometer-scale space such as the inside of cells, protein molecules diffuse throughout the cell interior within seconds. In this condition, how can ABPs selectively bind to particular actin filaments when there is an abundance of actin filaments in the cytoplasm? In recent years, several ABPs have been reported to induce cooperative conformational changes to actin filaments allowing structural changes to propagate along the filament cables uni- or bidirectionally, thereby regulating the subsequent binding of ABPs. Such propagation of ABP-induced cooperative conformational changes in actin filaments may be advantageous for the elaborate regulation of cellular activities driven by actin-based machineries in the intracellular space, which is dominated by diffusion. In this review, we focus on long-range allosteric regulation driven by cooperative conformational changes of actin filaments that are evoked by binding of ABPs, and discuss roles of allostery of actin filaments in narrow intracellular spaces. MDPI 2020-05-01 /pmc/articles/PMC7246755/ /pubmed/32370032 http://dx.doi.org/10.3390/ijms21093209 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tokuraku, Kiyotaka
Kuragano, Masahiro
Uyeda, Taro Q. P.
Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title_full Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title_fullStr Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title_full_unstemmed Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title_short Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities
title_sort long-range and directional allostery of actin filaments plays important roles in various cellular activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246755/
https://www.ncbi.nlm.nih.gov/pubmed/32370032
http://dx.doi.org/10.3390/ijms21093209
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