Chronic Systemic Exposure to Low-Dose Rotenone Induced Central and Peripheral Neuropathology and Motor Deficits in Mice: Reproducible Animal Model of Parkinson’s Disease

Epidemiological studies demonstrated that pesticide exposure, such as rotenone and paraquat, increases the risk of Parkinson’s disease (PD). Chronic systemic exposure to rotenone, a mitochondrial complex I inhibitor, could reproduce many features of PD. However, the adoption of the models is limitin...

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Detalles Bibliográficos
Autores principales: Miyazaki, Ikuko, Isooka, Nami, Imafuku, Fuminori, Sun, Jin, Kikuoka, Ryo, Furukawa, Chieko, Asanuma, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246801/
https://www.ncbi.nlm.nih.gov/pubmed/32375371
http://dx.doi.org/10.3390/ijms21093254

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