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Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of r...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246859/ https://www.ncbi.nlm.nih.gov/pubmed/32370092 http://dx.doi.org/10.3390/ijms21093215 |
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author | van Duursen, Majorie B. M. Boberg, Julie Christiansen, Sofie Connolly, Lisa Damdimopoulou, Pauliina Filis, Panagiotis Fowler, Paul A. Gadella, Bart M. Holte, Jan Jääger, Kersti Johansson, Hanna K. L. Li, Tianyi Mazaud-Guittot, Séverine Parent, Anne-Simone Salumets, Andres Soto, Ana M. Svingen, Terje Velthut-Meikas, Agne Bay Wedebye, Eva Xie, Yuling van den Berg, Martin |
author_facet | van Duursen, Majorie B. M. Boberg, Julie Christiansen, Sofie Connolly, Lisa Damdimopoulou, Pauliina Filis, Panagiotis Fowler, Paul A. Gadella, Bart M. Holte, Jan Jääger, Kersti Johansson, Hanna K. L. Li, Tianyi Mazaud-Guittot, Séverine Parent, Anne-Simone Salumets, Andres Soto, Ana M. Svingen, Terje Velthut-Meikas, Agne Bay Wedebye, Eva Xie, Yuling van den Berg, Martin |
author_sort | van Duursen, Majorie B. M. |
collection | PubMed |
description | Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally. |
format | Online Article Text |
id | pubmed-7246859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72468592020-06-02 Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project van Duursen, Majorie B. M. Boberg, Julie Christiansen, Sofie Connolly, Lisa Damdimopoulou, Pauliina Filis, Panagiotis Fowler, Paul A. Gadella, Bart M. Holte, Jan Jääger, Kersti Johansson, Hanna K. L. Li, Tianyi Mazaud-Guittot, Séverine Parent, Anne-Simone Salumets, Andres Soto, Ana M. Svingen, Terje Velthut-Meikas, Agne Bay Wedebye, Eva Xie, Yuling van den Berg, Martin Int J Mol Sci Project Report Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally. MDPI 2020-05-01 /pmc/articles/PMC7246859/ /pubmed/32370092 http://dx.doi.org/10.3390/ijms21093215 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Project Report van Duursen, Majorie B. M. Boberg, Julie Christiansen, Sofie Connolly, Lisa Damdimopoulou, Pauliina Filis, Panagiotis Fowler, Paul A. Gadella, Bart M. Holte, Jan Jääger, Kersti Johansson, Hanna K. L. Li, Tianyi Mazaud-Guittot, Séverine Parent, Anne-Simone Salumets, Andres Soto, Ana M. Svingen, Terje Velthut-Meikas, Agne Bay Wedebye, Eva Xie, Yuling van den Berg, Martin Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title | Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title_full | Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title_fullStr | Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title_full_unstemmed | Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title_short | Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project |
title_sort | safeguarding female reproductive health against endocrine disrupting chemicals—the freia project |
topic | Project Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246859/ https://www.ncbi.nlm.nih.gov/pubmed/32370092 http://dx.doi.org/10.3390/ijms21093215 |
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