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Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of r...

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Autores principales: van Duursen, Majorie B. M., Boberg, Julie, Christiansen, Sofie, Connolly, Lisa, Damdimopoulou, Pauliina, Filis, Panagiotis, Fowler, Paul A., Gadella, Bart M., Holte, Jan, Jääger, Kersti, Johansson, Hanna K. L., Li, Tianyi, Mazaud-Guittot, Séverine, Parent, Anne-Simone, Salumets, Andres, Soto, Ana M., Svingen, Terje, Velthut-Meikas, Agne, Bay Wedebye, Eva, Xie, Yuling, van den Berg, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246859/
https://www.ncbi.nlm.nih.gov/pubmed/32370092
http://dx.doi.org/10.3390/ijms21093215
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author van Duursen, Majorie B. M.
Boberg, Julie
Christiansen, Sofie
Connolly, Lisa
Damdimopoulou, Pauliina
Filis, Panagiotis
Fowler, Paul A.
Gadella, Bart M.
Holte, Jan
Jääger, Kersti
Johansson, Hanna K. L.
Li, Tianyi
Mazaud-Guittot, Séverine
Parent, Anne-Simone
Salumets, Andres
Soto, Ana M.
Svingen, Terje
Velthut-Meikas, Agne
Bay Wedebye, Eva
Xie, Yuling
van den Berg, Martin
author_facet van Duursen, Majorie B. M.
Boberg, Julie
Christiansen, Sofie
Connolly, Lisa
Damdimopoulou, Pauliina
Filis, Panagiotis
Fowler, Paul A.
Gadella, Bart M.
Holte, Jan
Jääger, Kersti
Johansson, Hanna K. L.
Li, Tianyi
Mazaud-Guittot, Séverine
Parent, Anne-Simone
Salumets, Andres
Soto, Ana M.
Svingen, Terje
Velthut-Meikas, Agne
Bay Wedebye, Eva
Xie, Yuling
van den Berg, Martin
author_sort van Duursen, Majorie B. M.
collection PubMed
description Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally.
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spelling pubmed-72468592020-06-02 Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project van Duursen, Majorie B. M. Boberg, Julie Christiansen, Sofie Connolly, Lisa Damdimopoulou, Pauliina Filis, Panagiotis Fowler, Paul A. Gadella, Bart M. Holte, Jan Jääger, Kersti Johansson, Hanna K. L. Li, Tianyi Mazaud-Guittot, Séverine Parent, Anne-Simone Salumets, Andres Soto, Ana M. Svingen, Terje Velthut-Meikas, Agne Bay Wedebye, Eva Xie, Yuling van den Berg, Martin Int J Mol Sci Project Report Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally. MDPI 2020-05-01 /pmc/articles/PMC7246859/ /pubmed/32370092 http://dx.doi.org/10.3390/ijms21093215 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Project Report
van Duursen, Majorie B. M.
Boberg, Julie
Christiansen, Sofie
Connolly, Lisa
Damdimopoulou, Pauliina
Filis, Panagiotis
Fowler, Paul A.
Gadella, Bart M.
Holte, Jan
Jääger, Kersti
Johansson, Hanna K. L.
Li, Tianyi
Mazaud-Guittot, Séverine
Parent, Anne-Simone
Salumets, Andres
Soto, Ana M.
Svingen, Terje
Velthut-Meikas, Agne
Bay Wedebye, Eva
Xie, Yuling
van den Berg, Martin
Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title_full Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title_fullStr Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title_full_unstemmed Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title_short Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
title_sort safeguarding female reproductive health against endocrine disrupting chemicals—the freia project
topic Project Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246859/
https://www.ncbi.nlm.nih.gov/pubmed/32370092
http://dx.doi.org/10.3390/ijms21093215
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