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Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery

Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we review the molecular targets and mechanisms of action of these compounds, framing them within the steps of RNAPII transcription. We discuss th...

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Detalles Bibliográficos
Autores principales:	Martin, Ryan D., Hébert, Terence E., Tanny, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246882/ https://www.ncbi.nlm.nih.gov/pubmed/32397434 http://dx.doi.org/10.3390/ijms21093354

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