The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline th...

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Detalles Bibliográficos
Autores principales: Panera, Nadia, Tozzi, Alberto Eugenio, Alisi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Current Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246970/
https://www.ncbi.nlm.nih.gov/pubmed/32451923
http://dx.doi.org/10.1007/s40265-020-01321-z
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author Panera, Nadia
Tozzi, Alberto Eugenio
Alisi, Anna
author_facet Panera, Nadia
Tozzi, Alberto Eugenio
Alisi, Anna
author_sort Panera, Nadia
collection PubMed
description G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
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spelling pubmed-72469702020-05-26 The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19 Panera, Nadia Tozzi, Alberto Eugenio Alisi, Anna Drugs Current Opinion G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic. Springer International Publishing 2020-05-25 2020 /pmc/articles/PMC7246970/ /pubmed/32451923 http://dx.doi.org/10.1007/s40265-020-01321-z Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Current Opinion
Panera, Nadia
Tozzi, Alberto Eugenio
Alisi, Anna
The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title_full The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title_fullStr The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title_full_unstemmed The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title_short The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
title_sort g-quadruplex/helicase world as a potential antiviral approach against covid-19
topic Current Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246970/
https://www.ncbi.nlm.nih.gov/pubmed/32451923
http://dx.doi.org/10.1007/s40265-020-01321-z
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