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Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders

The linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin ligase composed of the Heme-oxidized IRP2 ubiquitin ligase-1L (HOIL-1L), HOIL-1L-interacting protein (HOIP), and Shank-associated RH domain interactor (SHARPIN) subunits. LUBAC specifically generates the N-terminal Met1-linked linear...

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Detalles Bibliográficos
Autores principales: Oikawa, Daisuke, Sato, Yusuke, Ito, Hidefumi, Tokunaga, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246992/
https://www.ncbi.nlm.nih.gov/pubmed/32403254
http://dx.doi.org/10.3390/ijms21093381