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Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey
INTRODUCTION: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. AIM: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. MATERIAL AND METHODS: The files of 196 pemphigus patients admitted to our clinic between December 1995 and Dece...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247063/ https://www.ncbi.nlm.nih.gov/pubmed/32467679 http://dx.doi.org/10.5114/ada.2020.93380 |
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author | Kavala, Mukaddes Zindancı, İlkin Turkoglu, Zafer Kuru, Burce Can Ozlu, Emin Simsek, Mehmet |
author_facet | Kavala, Mukaddes Zindancı, İlkin Turkoglu, Zafer Kuru, Burce Can Ozlu, Emin Simsek, Mehmet |
author_sort | Kavala, Mukaddes |
collection | PubMed |
description | INTRODUCTION: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. AIM: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. MATERIAL AND METHODS: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. RESULTS: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 ±2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 ±1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. CONCLUSIONS: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis. |
format | Online Article Text |
id | pubmed-7247063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-72470632020-05-27 Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey Kavala, Mukaddes Zindancı, İlkin Turkoglu, Zafer Kuru, Burce Can Ozlu, Emin Simsek, Mehmet Postepy Dermatol Alergol Original Paper INTRODUCTION: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. AIM: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. MATERIAL AND METHODS: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. RESULTS: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 ±2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 ±1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. CONCLUSIONS: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis. Termedia Publishing House 2020-03-09 2020-02 /pmc/articles/PMC7247063/ /pubmed/32467679 http://dx.doi.org/10.5114/ada.2020.93380 Text en Copyright: © 2020 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Kavala, Mukaddes Zindancı, İlkin Turkoglu, Zafer Kuru, Burce Can Ozlu, Emin Simsek, Mehmet Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title | Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title_full | Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title_fullStr | Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title_full_unstemmed | Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title_short | Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey |
title_sort | nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in istanbul, turkey |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247063/ https://www.ncbi.nlm.nih.gov/pubmed/32467679 http://dx.doi.org/10.5114/ada.2020.93380 |
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