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Thiol/disulphide balance in patients with psoriasis
INTRODUCTION: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis. AIM: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group. MATERIAL AND METHODS: Eighty patients with psoriasis and 80 healthy individu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247074/ https://www.ncbi.nlm.nih.gov/pubmed/32467684 http://dx.doi.org/10.5114/ada.2018.77767 |
Sumario: | INTRODUCTION: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis. AIM: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group. MATERIAL AND METHODS: Eighty patients with psoriasis and 80 healthy individuals who were age- and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol were calculated. RESULTS: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05). CONCLUSIONS: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis. |
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