Structure-based screening of chemical libraries to identify small molecules that are likely to bind with the SET and RING-associated (SRA) domain of Ubiquitin-like, PHD and Ring Finger-containing 1 (UHRF1)

OBJECTIVES: UHRF1 is a multi-domain protein that recognizes both histone and DNA modification marks on chromatin. UHRF1 is involved in various cellular processes that lead to tumorigenesis and thus attracted considerable attention as a potential anti-cancer drug target. The SRA domain is a unique to...

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Detalles Bibliográficos
Autor principal: Patnaik, Debasis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Data Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247125/
https://www.ncbi.nlm.nih.gov/pubmed/32448288
http://dx.doi.org/10.1186/s13104-020-05103-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247125/
https://www.ncbi.nlm.nih.gov/pubmed/32448288
http://dx.doi.org/10.1186/s13104-020-05103-4

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