Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex

A detailed understanding of the molecular pathways for amyloid-β (Aβ) peptide aggregation from monomers into amyloid fibrils, a hallmark of Alzheimer's disease, is crucial for the development of diagnostic and therapeutic strategies. We investigate the molecular details of peptide fibrillizatio...

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Detalles Bibliográficos
Autores principales: Wallin, Cecilia, Jarvet, Jüri, Biverstål, Henrik, Wärmländer, Sebastian, Danielsson, Jens, Gräslund, Astrid, Abelein, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247290/
https://www.ncbi.nlm.nih.gov/pubmed/32241918
http://dx.doi.org/10.1074/jbc.RA120.012738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247290/
https://www.ncbi.nlm.nih.gov/pubmed/32241918
http://dx.doi.org/10.1074/jbc.RA120.012738

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