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Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

The premelanosomal protein (PMEL17) forms functional amyloid fibrils involved in melanin biosynthesis. Multiple PMEL17 isoforms are produced, two of which arise from excision of a cryptic intron within the amyloid-forming repeat (RPT) domain, leading to long (lRPT) and short (sRPT) isoforms with 10...

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Detalles Bibliográficos
Autores principales:	Dean, Dexter N., Lee, Jennifer C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247297/ https://www.ncbi.nlm.nih.gov/pubmed/32277052 http://dx.doi.org/10.1074/jbc.RA120.013012

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