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Enhancing the antigenicity and immunogenicity of monomeric forms of hepatitis C virus E2 for use as a preventive vaccine

The E2 glycoprotein of hepatitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critical for the efficacy of a prophylactic HCV vaccine. We previously showed that a cell culture–derived, disulfide-linked high-molecular-weight (HMW) form of the E2 receptor–bindi...

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Detalles Bibliográficos
Autores principales:	Center, Rob J., Boo, Irene, Phu, Lilian, McGregor, Joey, Poumbourios, Pantelis, Drummer, Heidi E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247312/ https://www.ncbi.nlm.nih.gov/pubmed/32299914 http://dx.doi.org/10.1074/jbc.RA120.013015

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